Genetic modelling in schizophrenia according to HLA typing

E. Smeraldi, F. Macciardi, M. Gasperini, A. Orsini, L. Bellodi, G. Fabio, A. Morabito

Research output: Contribution to journalArticlepeer-review


Studying families of schizophrenic patients, we observed that the risk of developing the overt form of the illness could be enhanced by some factors. Among these various factors we focused our attention on a biological variable, namely the presence or the absence of particular HLA antigens: partitioning our schizophrenic patients according to their HLA structure (i.e. those with HLA-A1 or CRAG-A1 antigens and those with HLA-non-CRAG-A1 antigens, respectively), revealed different illness distribution in the two groups. From a genetic point of view, this finding suggests the presence of heterogeneity in the hypothelical liability system related to schizophrenia and we evaluated the heterogeneity hypothesis by applying alternative genetic models to our data, trying to detect more biologically homogeneous subgroups of the disease.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalClinical Genetics
Issue number3
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics


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