Genetic Modification of T Cells

Chiara Bonini, Malcolm K. Brenner, Helen E. Heslop, Richard A. Morgan

Research output: Contribution to journalArticle

Abstract

Adoptively transferred T cells have shown activity in treating viral infections after hemopoietic transplantation and anti-tumor activity against some malignancies such as melanoma and lymphoma. Current research focuses on defining the optimum type of cell for transfer to improve persistence and genetically modifying infused T cells to augment function, overcome tumor evasion strategies and allow ablation should adverse effects occur.

Original languageEnglish
JournalBiology of Blood and Marrow Transplantation
Volume17
Issue number1 SUPPL
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Gene transfer
  • Suicide genes
  • T lymphocytes

ASJC Scopus subject areas

  • Transplantation
  • Hematology

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