Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica: Nostra esperienza

Translated title of the contribution: Genetic mutations, acquired disorders and obstetric pathology. Personal experience

P. Arcadia, A. G. Cosco, A. M. Ierullo, S. Palomba, R. Guarany, G. Muleo, R. Santoro, F. Zullo

Research output: Contribution to journalArticle

Abstract

Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems. Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B). Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A. Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.

Original languageItalian
Pages (from-to)9-13
Number of pages5
JournalMinerva Ginecologica
Volume54
Issue number1
Publication statusPublished - Feb 2002

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Obstetrics
Pathology
Mutation
Prothrombin
Factor V
Pregnancy Complications
Reproductive History
Control Groups
Antiphospholipid Syndrome
Incidence
Hemostasis
Anti-Idiotypic Antibodies
Phospholipids
Oxidoreductases
Genotype
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Arcadia, P., Cosco, A. G., Ierullo, A. M., Palomba, S., Guarany, R., Muleo, G., ... Zullo, F. (2002). Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica: Nostra esperienza. Minerva Ginecologica, 54(1), 9-13.

Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica : Nostra esperienza. / Arcadia, P.; Cosco, A. G.; Ierullo, A. M.; Palomba, S.; Guarany, R.; Muleo, G.; Santoro, R.; Zullo, F.

In: Minerva Ginecologica, Vol. 54, No. 1, 02.2002, p. 9-13.

Research output: Contribution to journalArticle

Arcadia, P, Cosco, AG, Ierullo, AM, Palomba, S, Guarany, R, Muleo, G, Santoro, R & Zullo, F 2002, 'Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica: Nostra esperienza', Minerva Ginecologica, vol. 54, no. 1, pp. 9-13.
Arcadia P, Cosco AG, Ierullo AM, Palomba S, Guarany R, Muleo G et al. Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica: Nostra esperienza. Minerva Ginecologica. 2002 Feb;54(1):9-13.
Arcadia, P. ; Cosco, A. G. ; Ierullo, A. M. ; Palomba, S. ; Guarany, R. ; Muleo, G. ; Santoro, R. ; Zullo, F. / Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica : Nostra esperienza. In: Minerva Ginecologica. 2002 ; Vol. 54, No. 1. pp. 9-13.
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