Abstract
Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems. Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B). Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A. Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.
| Original language | Italian |
|---|---|
| Pages (from-to) | 9-13 |
| Number of pages | 5 |
| Journal | Minerva Ginecologica |
| Volume | 54 |
| Issue number | 1 |
| Publication status | Published - Feb 2002 |
Fingerprint
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica : Nostra esperienza. / Arcadia, P.; Cosco, A. G.; Ierullo, A. M.; Palomba, S.; Guarany, R.; Muleo, G.; Santoro, R.; Zullo, F.
In: Minerva Ginecologica, Vol. 54, No. 1, 02.2002, p. 9-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica
T2 - Nostra esperienza
AU - Arcadia, P.
AU - Cosco, A. G.
AU - Ierullo, A. M.
AU - Palomba, S.
AU - Guarany, R.
AU - Muleo, G.
AU - Santoro, R.
AU - Zullo, F.
PY - 2002/2
Y1 - 2002/2
N2 - Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems. Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B). Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A. Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.
AB - Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems. Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B). Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A. Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.
KW - Blood coagulation disorders, diagnosis
KW - Blood coagulation disorders, genetics
KW - Pregnancy, genetics
UR - http://www.scopus.com/inward/record.url?scp=0036481393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036481393&partnerID=8YFLogxK
M3 - Articolo
C2 - 11828266
AN - SCOPUS:0036481393
VL - 54
SP - 9
EP - 13
JO - Minerva Ginecologica
JF - Minerva Ginecologica
SN - 0026-4784
IS - 1
ER -