Mutazioni genetiche, disordini acquisiti nel sistema coagulativo e patologia ostetrica: Nostra esperienza

Translated title of the contribution: Genetic mutations, acquired disorders and obstetric pathology. Personal experience

P. Arcadia, A. G. Cosco, A. M. Ierullo, S. Palomba, R. Guarany, G. Muleo, R. Santoro, F. Zullo

Research output: Contribution to journalArticlepeer-review


Background. To evaluate the incidence of thrombophilic disorders such as Factor II mutation, Leiden factor V and MTHFR genotype, and anti-phosholipid anti-bodies syndrome in women with or without pregnancy related problems. Methods. Sixty-three patients (group A) with pregnancy complications were included in the study and tested for Factor V mutation, Factor II mutation, 5-10 MTHFR reductase mutation and anti-phospholipid antibodies syndrome. The incidence of disorders was compared with thirty-six pregnancies without complications (control study, group B). Results. Hemostasis thrombophilic like disorders, were significantly high (p=0.001 vs group B). Nobody in both groups was homozigous for Leiden mutation or prothrombin mutation (Factor II). The prevalence of Factor V mutation in heterozygosis was significantly (p=0.01) higher in group A in comparison with group B. The MTHFR mutation in homozygosis was found in 21.4% of group A while in the control group it was 11%. Factor II mutation in heterozygosis and anti-phospholipid antibodies were found only in group A. Conclusions. It is important to evaluate the hemocoaugulation patterns in women with a history of complicated pregnancies.

Translated title of the contributionGenetic mutations, acquired disorders and obstetric pathology. Personal experience
Original languageItalian
Pages (from-to)9-13
Number of pages5
JournalMinerva Ginecologica
Issue number1
Publication statusPublished - Feb 2002

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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