Genetic pathways and histogenetic models of AIDS-related lymphomas

A. Carbone, A. Gloghini, D. Capello, G. Gaidano

Research output: Contribution to journalArticle

Abstract

Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.

Original languageEnglish
Pages (from-to)1270-1275
Number of pages6
JournalEuropean Journal of Cancer
Volume37
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • AIDS
  • Histogenesis
  • Lymphomas
  • Pathogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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