Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome

Huansheng Xu, Antonio Baldini

Research output: Contribution to journalArticlepeer-review

Abstract

Mammalian heart development requires multiple genetic networks, only some of which are becoming known in all their complexity. Substantial new information has become available thanks to an expanding toolkit that offers more and more mouse gene manipulation options, and that is taking the mouse closer to more powerful invertebrate genetic models. We review examples of recent data with a cardiac-lineage-based view of heart development, especially outflow tract and right ventricle. The medical significance of these studies is not only relevant to congenital heart disease, but also to the biology of cardiac cell regeneration.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Cardiac outflow tract
  • Cardiogenic lineages
  • Genetic control of heart development
  • Review
  • T-box

ASJC Scopus subject areas

  • Developmental Biology

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