TY - JOUR
T1 - Genetic pathways to mammalian heart development
T2 - Recent progress from manipulation of the mouse genome
AU - Xu, Huansheng
AU - Baldini, Antonio
PY - 2007/2
Y1 - 2007/2
N2 - Mammalian heart development requires multiple genetic networks, only some of which are becoming known in all their complexity. Substantial new information has become available thanks to an expanding toolkit that offers more and more mouse gene manipulation options, and that is taking the mouse closer to more powerful invertebrate genetic models. We review examples of recent data with a cardiac-lineage-based view of heart development, especially outflow tract and right ventricle. The medical significance of these studies is not only relevant to congenital heart disease, but also to the biology of cardiac cell regeneration.
AB - Mammalian heart development requires multiple genetic networks, only some of which are becoming known in all their complexity. Substantial new information has become available thanks to an expanding toolkit that offers more and more mouse gene manipulation options, and that is taking the mouse closer to more powerful invertebrate genetic models. We review examples of recent data with a cardiac-lineage-based view of heart development, especially outflow tract and right ventricle. The medical significance of these studies is not only relevant to congenital heart disease, but also to the biology of cardiac cell regeneration.
KW - Cardiac outflow tract
KW - Cardiogenic lineages
KW - Genetic control of heart development
KW - Review
KW - T-box
UR - http://www.scopus.com/inward/record.url?scp=33847250352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847250352&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2006.11.011
DO - 10.1016/j.semcdb.2006.11.011
M3 - Article
C2 - 17178242
AN - SCOPUS:33847250352
VL - 18
SP - 77
EP - 83
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
SN - 1084-9521
IS - 1
ER -