Genetic polymorphisms and the development of invasive bacterial infections in children

Susanna Esposito, Samantha Bosis, Annalisa Orenti, Silvia Spena, Valentina Montinaro, Sonia Bianchini, Alberto Zampiero, Nicola Principi

Research output: Contribution to journalArticle

Abstract

To evaluate the associations between single nucleotide polymorphisms (SNPs) of factors involved in the development of invasive bacterial disease (IBD) in children, 47 SNPs of 18 candidate genes were analysed in 49 children with IBD and 100 controls. The G/T genotype of TLR2 rs2149356 and the C genotype of LTA rs2229094 were associated with significantly reduced risk of developing IBD (P = 0.04 and P = 0.05, respectively), whereas the C/T genotype of RFP175 rs1585110 was associated with a significantly higher risk of developing IBD (P = 0.02). These results support the evidence that some genetic variants of factors involved in innate immunity may influence IBD risk in children.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume29
Issue number1
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • adaptive immunity
  • genetic polymorphisms
  • innate immunity
  • invasive bacterial disease
  • Neisseria meningitidis
  • sepsis
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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