Genetic polymorphisms in an aged population: Comparisons with a large population of subjects and with young survivors of myocardial infarction

Luigi Colombo, Maurizio Margaglione, Nicola Colombo, Antonio Russo, Alberico L. Catapano

Research output: Contribution to journalArticle

Abstract

Objective: Myocardial infarction is the most common cause of death and of disability in Western countries. In recent years, an increasing interest in genetic risk factors has emerged. The overall influence of genes on the risk of myocardial infarction is ill defined. This study investigates the prevalence of a series of polymorphisms in gene loci involved in coagulation, fibrinolysis and other metabolic pathways in a setting of young survivors who underwent an episode of myocardial infarction before the age of 55 years. Methods: These data have been compared with those found in a setting of aged individuals without myocardial infarction and with a group of general population from the same geographic area. Functional polymorphisms of several genes involved in haemostasis lipid metabolism and hypertension were valuated and allelic frequencies estimated. Results: In the group of patients with myocardial infarction, the frequency observed for the FVII M2M2 genotype was significantly lower than that observed in aged individuals (p = 0.02). A similar trend was observed when the general population was taken into account. The ACE DD genotype frequency significantly differed between patients with a history of myocardial infarction and aged individuals (p = 0.04), whereas the difference approached a significant level when the general population was taken into account (p = 0.07). All other genotype frequencies did not differ among groups. Conclusions: Our data support the concept that ACE and FVII genes are susceptibility loci, i.e. they are neither necessary nor sufficient for the disease to occur, but make it more likely that one will become ill. The extent to which these polymorphisms confer an additional cardiovascular risk, mainly at young age, has to be addressed in prospective studies.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalHigh Blood Pressure and Cardiovascular Prevention
Volume14
Issue number2
DOIs
Publication statusPublished - 2007

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Keywords

  • Genes
  • Myocardial infarction
  • Population
  • Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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