Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients

Milena Nasi, Marcello Pinti, Roberto Bugarini, Leonarda Troiano, Enrico Lugli, Cristian Bellodi, Cristina Mussini, Vanni Borghi, Tommaso Trenti, Fiorella Balli, Roberto Esposito, Andrea Cossarizza

Research output: Contribution to journalArticlepeer-review

Abstract

Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation. A strong debate exists on the importance of Fas/FasL system during HIV infection, which is characterized by the loss of CD4+ T cells directly, or indirectly, caused by the virus. To investigate whether the genetic background of the host plays a role in the immunoreconstitution, we studied the influence of different Fas and FasL polymorphisms on CD4+ T lymphocyte count and plasma viral load following initiation of highly active antiretroviral therapy (HAART) in drug-naïve HIV+ patients. We studied 131 individuals, who were compared to 136 healthy donors. Statistical analysis was performed by using X 2 test, Fischer's Exact Test, and analysis for repeated measurements. The group of HIV+ patients had an unexpected lower frequency of FasLnt169 polymorphism (delT allele) than healthy controls (p=0.039). We then observed no significant differences in the immune reconstitution, in terms of CD4+ T cell increase, when the influence of single alleles of the gene Fas or FasL was considered. However, the combination of some polymorphisms of Fas or FasL significantly influenced CD4+ T cell production and viral load decrease, showing that these genes can play a role in the immunoreconstitution triggered by antiretroviral therapy.

Original languageEnglish
Pages (from-to)628-635
Number of pages8
JournalImmunogenetics
Volume57
Issue number9
DOIs
Publication statusPublished - Oct 2005

Keywords

  • AIDS
  • Apoptosis
  • CD178/CD95L/FasL gene polymorphism
  • CD95/Apo-1/Fas gene polymorphism
  • HAART
  • HIV

ASJC Scopus subject areas

  • Immunology
  • Genetics

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