Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: Studies on centenarians

M. Pinti, L. Troiano, M. Nasi, L. Moretti, E. Monterastelli, A. Mazzacani, C. Mussi, P. Ventura, F. Olivieri, C. Franceschi, G. Salvioli, A. Cossarizza

Research output: Contribution to journalArticlepeer-review

Abstract

Apoptosis plays a crucial role in immunosenescence, as also evidenced by the increased expression of Fas in lymphocytes from aged people. However, little is known about the genetic regulation of Fas and its ligand, FasL. We have studied their polymorphisms in 50 centenarians and 86 young donors living in Northern Italy. The first Fas polymorphism, at position -670, has in Caucasian a heterozygosity of 51%; the second, at -1377 position, has the wild type allele (G) with a very high frequency (83%) respect to the mutant allele. Genotype and allele distribution for both polymorphisms were similar in controls and centenarians. Similar results were found as far as two FasL polymorphisms (IVS2nt-124 and IVS3nt169) are concerned. On the whole, our data suggest that Fas and FasL polymorphisms, as well as their haplotypes, are unlikely to be associated with successful human longevity.

Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalCell Death and Differentiation
Volume9
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Aging
  • Apoptosis
  • CD178/FasL gene polymorphism
  • CD95/Apo-1/Fas gene

ASJC Scopus subject areas

  • Cell Biology

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