TY - JOUR
T1 - Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity
T2 - Studies on centenarians
AU - Pinti, M.
AU - Troiano, L.
AU - Nasi, M.
AU - Moretti, L.
AU - Monterastelli, E.
AU - Mazzacani, A.
AU - Mussi, C.
AU - Ventura, P.
AU - Olivieri, F.
AU - Franceschi, C.
AU - Salvioli, G.
AU - Cossarizza, A.
PY - 2002
Y1 - 2002
N2 - Apoptosis plays a crucial role in immunosenescence, as also evidenced by the increased expression of Fas in lymphocytes from aged people. However, little is known about the genetic regulation of Fas and its ligand, FasL. We have studied their polymorphisms in 50 centenarians and 86 young donors living in Northern Italy. The first Fas polymorphism, at position -670, has in Caucasian a heterozygosity of 51%; the second, at -1377 position, has the wild type allele (G) with a very high frequency (83%) respect to the mutant allele. Genotype and allele distribution for both polymorphisms were similar in controls and centenarians. Similar results were found as far as two FasL polymorphisms (IVS2nt-124 and IVS3nt169) are concerned. On the whole, our data suggest that Fas and FasL polymorphisms, as well as their haplotypes, are unlikely to be associated with successful human longevity.
AB - Apoptosis plays a crucial role in immunosenescence, as also evidenced by the increased expression of Fas in lymphocytes from aged people. However, little is known about the genetic regulation of Fas and its ligand, FasL. We have studied their polymorphisms in 50 centenarians and 86 young donors living in Northern Italy. The first Fas polymorphism, at position -670, has in Caucasian a heterozygosity of 51%; the second, at -1377 position, has the wild type allele (G) with a very high frequency (83%) respect to the mutant allele. Genotype and allele distribution for both polymorphisms were similar in controls and centenarians. Similar results were found as far as two FasL polymorphisms (IVS2nt-124 and IVS3nt169) are concerned. On the whole, our data suggest that Fas and FasL polymorphisms, as well as their haplotypes, are unlikely to be associated with successful human longevity.
KW - Aging
KW - Apoptosis
KW - CD178/FasL gene polymorphism
KW - CD95/Apo-1/Fas gene
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U2 - 10.1038/sj.cdd.4400964
DO - 10.1038/sj.cdd.4400964
M3 - Article
C2 - 11965496
AN - SCOPUS:18444413231
VL - 9
SP - 431
EP - 438
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
SN - 1350-9047
IS - 4
ER -