Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia

Paolo Gravina, Ilaria Spoletini, Silvia Masini, Alessandra Valentini, Diego Vanni, Eleonora Paladini, Paola Bossù, Carlo Caltagirone, Giorgio Federici, Gianfranco Spalletta, Sergio Bernardini

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.

Original languageEnglish
Pages (from-to)454-456
Number of pages3
JournalPsychiatry Research
Volume187
Issue number3
DOIs
Publication statusPublished - May 30 2011

Keywords

  • Glutathione S-transferases
  • Reactive oxygen species
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint

Dive into the research topics of 'Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia'. Together they form a unique fingerprint.

Cite this