TY - JOUR
T1 - Genetic polymorphisms of glutathione S-transferases GSTM1, GSTT1, GSTP1 and GSTA1 as risk factors for schizophrenia
AU - Gravina, Paolo
AU - Spoletini, Ilaria
AU - Masini, Silvia
AU - Valentini, Alessandra
AU - Vanni, Diego
AU - Paladini, Eleonora
AU - Bossù, Paola
AU - Caltagirone, Carlo
AU - Federici, Giorgio
AU - Spalletta, Gianfranco
AU - Bernardini, Sergio
PY - 2011/5/30
Y1 - 2011/5/30
N2 - Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.
AB - Oxidative damage is thought to play a role in the predisposition to schizophrenia. We determined if the polymorphisms of the GSTP1, GSTM1, GSTT1 and GSTA1 genes, which affect the activity of these enzymes against oxidative stress, have a role as susceptibility genes for schizophrenia, analyzing 138 schizophrenic patients and 133 healthy controls. We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.
KW - Glutathione S-transferases
KW - Reactive oxygen species
KW - Schizophrenia
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U2 - 10.1016/j.psychres.2010.10.008
DO - 10.1016/j.psychres.2010.10.008
M3 - Article
C2 - 21093063
AN - SCOPUS:79954571927
VL - 187
SP - 454
EP - 456
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 3
ER -