Genetic polymorphisms of IL28b gene as predictors of response to dual therapy in genotypes 1 and 4-HCV and HIV/HCV-infected patients

Laura Sticchi, Antonio Di Biagio, Marina Sartini, Emanuela Rappazzo, Laura A. Nicolini, Giovanni Cenderello, Caterina Valle, Emilio Azzola, Alessandro Grasso, Pasqualina De Leo, Alessandra Boldrini, Maurizio Setti, Roberta Prinapori, Carolina Lorusso, Bianca Bruzzone, Giancarlo Icardi, Anna I. Alessandrini, Valentina Bartolacci, Silvia Boni, Martina CoppelliChiara Dentone, Giovanni Mazzarello, Claudio Viscoli

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the genotypes and allele distribution of interleukin 28B (IL28B) rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) in hepatitis C virus (HCV) G1-4 infected patients, to assess predictive ability and to determine whether the combined determination of two IL28B SNPs might improve sustained virologic response (SVR) prediction of both in HCV mono- and HIV/HCV co-infected patients. IL28B SNPs were genotyped in 269 patients, 181 mono- and 88 co-infected, treated with pegylated interferon and ribavirin. Data stratified by HCV mono- and HCV/HIV co-infected patients showed that 58% and 31% of the rs12979860CC carriers and 49% and 21% of the rs8099917TT carriers had SVR. IL28B SNPs, HCV mono-infection and HCV RNA load were associated with SVR as independent predictors in the two study groups as a whole. ROC curve analyses in the two populations separately, based on gender, age, baseline HCV RNA load and rs12979860/rs8099917 revealed similar receiver operating characteristics (ROC) areas under the curve values. Combining the determination of IL28B SNPs, rs8099917 genotyping improved the response prediction in rs12979860CT carriers only in mono-infected patients. In the era of direct-acting antiviral agents, adopting SVR baseline predictors to orientate naive-patient management represents an important issue. A model involving IL28B SNPs appears able to predict SVR in both populations.

Original languageEnglish
Pages (from-to)499-509
Number of pages11
JournalNew Microbiologica
Volume38
Issue number4
Publication statusPublished - Oct 1 2015

Keywords

  • Hepatitis C virus-G1
  • Hepatitis C virus-G4
  • Human immunodeficiency virus
  • Interleukin-28B rs12979860
  • Interleukin-28B rs8099917

ASJC Scopus subject areas

  • Microbiology (medical)

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