Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer

Tasha R. Smith; Wen Liu-Mares; Beth O. van Emburgh; Edward A. Levine; Glenn O. Allen; Jeff W. Hill; Isildinha M. Reis; Laura A. Kresty; Mark D. Pegram; Mark S. Miller; Jennifer J. Hu

doi:10.1093/carcin/bgr117

Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer

Tasha R. Smith, Wen Liu-Mares, Beth O. van Emburgh, Edward A. Levine, Glenn O. Allen, Jeff W. Hill, Isildinha M. Reis, Laura A. Kresty, Mark D. Pegram, Mark S. Miller, Jennifer J. Hu

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Defective DNA repair may contribute to early age and late stage at time of diagnosis and mutations in critical tumor suppressor genes, such as TP53 in breast cancer. Using DNA samples from 436 breast cancer cases (374 Caucasians and 62 African-Americans), we tested these associations with 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways: (i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q and POLD1 R119H; (ii) double-strand break repair: NBS1 E185Q and XRCC3 T241M; (iii) mismatch repair: MLH1 I219V, MSH3 R940Q/T1036A andMSH6 G39E and (iv) nucleotide excision repair: ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H and XPC A499V/K939Q. Younger age at diagnosis (trend <0.001). A similar significant trend was also observed associating TP53 mutations with increasing numbers of risk genotypes for XRCC1 399 QQ, XPC 939 QQ, ERCC4 415 QQ and XPC 499 AA (P_trend <0.001). Our pilot data suggest that nsSNPs of multiple DNA repair pathways are associated with younger age at diagnosis and TP53 mutations in breast cancer and larger studies are warranted to further evaluate these associations.

Original language	English
Pages (from-to)	1354-1360
Number of pages	7
Journal	Carcinogenesis
Volume	32
Issue number	9
DOIs	https://doi.org/10.1093/carcin/bgr117
Publication status	Published - 2011

ASJC Scopus subject areas

Cancer Research

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10.1093/carcin/bgr117

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Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. / Smith, Tasha R.; Liu-Mares, Wen; van Emburgh, Beth O.; Levine, Edward A.; Allen, Glenn O.; Hill, Jeff W.; Reis, Isildinha M.; Kresty, Laura A.; Pegram, Mark D.; Miller, Mark S.; Hu, Jennifer J.

In: Carcinogenesis, Vol. 32, No. 9, 2011, p. 1354-1360.

Research output: Contribution to journal › Article › peer-review

Smith, Tasha R. ; Liu-Mares, Wen ; van Emburgh, Beth O. ; Levine, Edward A. ; Allen, Glenn O. ; Hill, Jeff W. ; Reis, Isildinha M. ; Kresty, Laura A. ; Pegram, Mark D. ; Miller, Mark S. ; Hu, Jennifer J. / Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer. In: Carcinogenesis. 2011 ; Vol. 32, No. 9. pp. 1354-1360.

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abstract = "Defective DNA repair may contribute to early age and late stage at time of diagnosis and mutations in critical tumor suppressor genes, such as TP53 in breast cancer. Using DNA samples from 436 breast cancer cases (374 Caucasians and 62 African-Americans), we tested these associations with 18 non-synonymous single-nucleotide polymorphisms (nsSNPs) in four DNA repair pathways: (i) base excision repair: ADPRT V762A, APE1 D148E, XRCC1 R194W/R280H/R399Q and POLD1 R119H; (ii) double-strand break repair: NBS1 E185Q and XRCC3 T241M; (iii) mismatch repair: MLH1 I219V, MSH3 R940Q/T1036A andMSH6 G39E and (iv) nucleotide excision repair: ERCC2 D312N/K751Q, ERCC4 R415Q, ERCC5 D1104H and XPC A499V/K939Q. Younger age at diagnosis (trend <0.001). A similar significant trend was also observed associating TP53 mutations with increasing numbers of risk genotypes for XRCC1 399 QQ, XPC 939 QQ, ERCC4 415 QQ and XPC 499 AA (Ptrend <0.001). Our pilot data suggest that nsSNPs of multiple DNA repair pathways are associated with younger age at diagnosis and TP53 mutations in breast cancer and larger studies are warranted to further evaluate these associations.",

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Genetic polymorphisms of multiple DNA repair pathways impact age at diagnosis and TP53 mutations in breast cancer

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