Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study)

Raffaella Buzzetti, A. Galgani, A. Petrone, M. L. Del Buono, H. A. Erlich, T. L. Bugawan, R. Lorini, F. Meschi, G. Multari, P. Pozzilli, M. Locatelli, G. Bottazzo, U. Di Mario

Research output: Contribution to journalArticle

Abstract

Background. To develop a sensitive, specific screening strategy for predicting genetic risk for type 1 diabetes mellitus (T1DM) in the low-incidence continental Italian population, and to define with this tool, a cohort of high-to-moderate risk infants for an immunological follow-up study aimed at identifying environmental risk factors for T1DM. Methods. 4855 newborns in three regions of continental Italy were screened for T1DM HLA-DRB1-DQB1 risk genotypes using a reverse line blot typing method. Risk classification was based on odds ratios (OR) found in a preliminary case-control study (356 T1DM patients, 412 controls). Screening efficiency was optimized by allele subtyping. Results. Screening for well-known T1DM susceptibility genotypes [DRB1*03/*04-DQB1*0302; DRB1*03/*03; DRB1*04/*04-DQB1*0302; DRB1*04-DQB1*0302/X where X ≠ DRB1*03, DRB1*04-DQB1*0302, DQB1*0602 or DQB1*0603] was associated with

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume20
Issue number2
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Genetics
  • Genotype frequency
  • HLA class II alleles
  • Incidence
  • Newborn screening
  • Prediction
  • Risk estimation
  • Sensitivity
  • Specificity
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study)'. Together they form a unique fingerprint.

  • Cite this

    Buzzetti, R., Galgani, A., Petrone, A., Del Buono, M. L., Erlich, H. A., Bugawan, T. L., Lorini, R., Meschi, F., Multari, G., Pozzilli, P., Locatelli, M., Bottazzo, G., & Di Mario, U. (2004). Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study). Diabetes/Metabolism Research and Reviews, 20(2), 137-143. https://doi.org/10.1002/dmrr.426