Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study)

Raffaella Buzzetti, A. Galgani, A. Petrone, M. L. Del Buono, H. A. Erlich, T. L. Bugawan, R. Lorini, F. Meschi, G. Multari, P. Pozzilli, M. Locatelli, G. Bottazzo, U. Di Mario

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background. To develop a sensitive, specific screening strategy for predicting genetic risk for type 1 diabetes mellitus (T1DM) in the low-incidence continental Italian population, and to define with this tool, a cohort of high-to-moderate risk infants for an immunological follow-up study aimed at identifying environmental risk factors for T1DM. Methods. 4855 newborns in three regions of continental Italy were screened for T1DM HLA-DRB1-DQB1 risk genotypes using a reverse line blot typing method. Risk classification was based on odds ratios (OR) found in a preliminary case-control study (356 T1DM patients, 412 controls). Screening efficiency was optimized by allele subtyping. Results. Screening for well-known T1DM susceptibility genotypes [DRB1*03/*04-DQB1*0302; DRB1*03/*03; DRB1*04/*04-DQB1*0302; DRB1*04-DQB1*0302/X where X ≠ DRB1*03, DRB1*04-DQB1*0302, DQB1*0602 or DQB1*0603] was associated with

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalDiabetes/Metabolism Research and Reviews
Volume20
Issue number2
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Medical problems
Type 1 Diabetes Mellitus
Genotype
Incidence
Screening
Population
HLA-DRB1 Chains
Italy
Case-Control Studies
Alleles
Odds Ratio
Newborn Infant
HLA-DQB1 antigen

Keywords

  • Genetics
  • Genotype frequency
  • HLA class II alleles
  • Incidence
  • Newborn screening
  • Prediction
  • Risk estimation
  • Sensitivity
  • Specificity
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study). / Buzzetti, Raffaella; Galgani, A.; Petrone, A.; Del Buono, M. L.; Erlich, H. A.; Bugawan, T. L.; Lorini, R.; Meschi, F.; Multari, G.; Pozzilli, P.; Locatelli, M.; Bottazzo, G.; Di Mario, U.

In: Diabetes/Metabolism Research and Reviews, Vol. 20, No. 2, 03.2004, p. 137-143.

Research output: Contribution to journalArticle

Buzzetti, R, Galgani, A, Petrone, A, Del Buono, ML, Erlich, HA, Bugawan, TL, Lorini, R, Meschi, F, Multari, G, Pozzilli, P, Locatelli, M, Bottazzo, G & Di Mario, U 2004, 'Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study)', Diabetes/Metabolism Research and Reviews, vol. 20, no. 2, pp. 137-143. https://doi.org/10.1002/dmrr.426
Buzzetti, Raffaella ; Galgani, A. ; Petrone, A. ; Del Buono, M. L. ; Erlich, H. A. ; Bugawan, T. L. ; Lorini, R. ; Meschi, F. ; Multari, G. ; Pozzilli, P. ; Locatelli, M. ; Bottazzo, G. ; Di Mario, U. / Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABGFIN study). In: Diabetes/Metabolism Research and Reviews. 2004 ; Vol. 20, No. 2. pp. 137-143.
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AU - Petrone, A.

AU - Del Buono, M. L.

AU - Erlich, H. A.

AU - Bugawan, T. L.

AU - Lorini, R.

AU - Meschi, F.

AU - Multari, G.

AU - Pozzilli, P.

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