Genetic predisposition to breast and ovarian cancer

M. Montagna, E. D'Andrea, M. Santacatterina, C. Menin, O. Nicoletto, L. Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review


The hereditary breast cancer syndrome accounts for up to 10% of all breast cancers and is characterised by a high level of genetic heterogeneity. Two major susceptibility genes, BRCA1 and BRCA2, have been identified to date, and are thought to be responsible for as many as 80% of all hereditary breast cancers. The risks associated with predisposing mutations in these genes are high, even if they may vary among families. The phenotype also varies (breast, ovarian and other cancers) and may be partly influenced by the location of the mutation within the gene sequence. While little is known regarding BRCA2 biological function, recent studies on BRCA1 suggest that it is probably involved in DNA recombination and/or repair processes.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalFORUM - Trends in Experimental and Clinical Medicine
Issue number1 SUPPL. 2
Publication statusPublished - 1997


  • BRCA genes
  • Breast and ovarian cancer syndrome
  • Genetic predisposition

ASJC Scopus subject areas

  • Medicine(all)


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