Genetic predisposition to hepatocarcinogenesis in inbred and outbred mouse lines selected for high or low inflammatory response

Lilian Rego De Carvalho, Andrea Borrego, José Ricardo Jensen, Wafa Hanna Koury Cabrera, Aline Marques Santos, Orlando Garcia Ribeiro, Nancy Starobinas, Marcelo De Franco, Tommaso A. Dragani, Giacomo Manenti, Olga Célia Martinez Ibañez

Research output: Contribution to journalArticle

Abstract

AIRmax and AIRmin mouse strains phenotypically selected for high and low acute inflammatory responsiveness (AIR) are, respectively, susceptible or resistant to developing hepatocellular carcinoma (HCC) induced by the chemical carcinogens urethane and diethylnitrosamine (DEN). Early production of TNF-α, IL-1β, and IL-6 in the liver after DEN treatment correlated with tumor development in AIRmax mice. Transcriptome analysis of livers from untreated AIRmax and AIRmin mice showed specific gene expression profiles in each line, which might play a role in their differential susceptibility to HCC. Linkage analysis with SNP markers in F2 (AIRmax×AIRmin) intercross mice revealed two quantitative trait loci (QTL) in chromosomes 2 and 9, which are significantly associated with the number and progression of urethane-induced liver tumors. An independent linkage analysis with an intercross population from A/J and C57BL/6J inbred mice mapped regions in chromosomes 1 and 7 associated with the progression of urethane-induced liver tumors, evidencing the heterogeneity of HCC genetic control.

Original languageEnglish
Article number5298792
JournalJournal of Immunology Research
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    De Carvalho, L. R., Borrego, A., Jensen, J. R., Cabrera, W. H. K., Santos, A. M., Ribeiro, O. G., Starobinas, N., De Franco, M., Dragani, T. A., Manenti, G., & Ibañez, O. C. M. (2019). Genetic predisposition to hepatocarcinogenesis in inbred and outbred mouse lines selected for high or low inflammatory response. Journal of Immunology Research, 2019, [5298792]. https://doi.org/10.1155/2019/5298792