Genetic profile identification in clinically localized prostate carcinoma

Michele Gallucci, Roberta Merola, Costantino Leonardo, Piero De Carli, Antonella Farsetti, Steno Sentinelli, Isabella Sperduti, Marcella Mottolese, Paolo Carlini, Erika Vico, Giuseppe Simone, AnnaMaria Cianciulli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To confirm our previously obtained results, we genetically characterized prostate cancer from patients undergo radical prostatectomy in a retrospective study. Materials and methods: Histological sections were evaluated for 106 patients treated with surgery from 1991 to 2004. With fluorescence in situ hybridization (FISH) method, the status of LPL (8p22), c-MYC (8q24) genes and 7, 8, X chromosomes was evaluated. Results: Chromosomes 7, 8, X aneusomy was demonstrated in 91.5%, 78.3%, and 51.9% of the samples, respectively, whereas LPL deletion and MYC amplification were found in 76.0% and 1.6%. A genetic profile was considered as unfavorable when at least two aneusomic chromosomes and one altered gene were present. Tumors with an adverse genetic profile were more frequently present in patients with higher stages (P = 0.02), biochemical/clinical progression (P = 0.03), and Gleason grade 4 + 3 (P = 0.02). Multiple correspondence analysis identified one tumor group characterized by chromosome 8 aneusomy, X polysomy, LPL gene deletion, Gleason > 7 and 4 + 3 associated with progression. Conclusions: In this study, we recognized the predictive power of previously identified cytogenetic profiles. Assessment of genetic set may characterize each patient and have influence on postoperative therapeutic strategies.

Original languageEnglish
Pages (from-to)502-508
Number of pages7
JournalUrologic Oncology: Seminars and Original Investigations
Volume27
Issue number5
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Cancer genetics
  • Chromosomal abnormalities
  • Prognostic studies
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology

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