Genetic rearrangements in the tyrB-uvrA region of the enterobacterial chromosome

A potential cause for different class B acid phosphatase regulation in Salmonella enterica and Escherichia coli

Maria Cristina Thaller, Serena Schippa, Alessandra Bonci, Francesca Berlutti, Laura Selan, Gian Maria Rossolini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Unlike in Escherichia coli, in Salmonella enterica production of class B acid phosphatase (AphA) was detectable also in cells growing in the presence of glucose. Characterization of the aphA locus from a S. enterica ser. typhi strain showed that the aphA determinant is very similar to the E. coli homolog, and that its chromosomal location between the highly conserved tyrB and uvrA genes is retained. However, the aphA flanking regions were found to be markedly different in the two species, either between tyrB and aphA or between aphA and uvrA. The differences in the aphA 5'-flanking region, which in S. enterica is considerably shorter than in E. coli (183 vs. 1121 bp) and includes potential promoter sequences not present in E. coli, could be responsible for the different regulation of class B acid phosphatase observed in the two species. Copyright (C) 1999 Federation of European Microbiological Societies.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalFEMS Microbiology Letters
Volume181
Issue number1
DOIs
Publication statusPublished - Dec 1 1999

Fingerprint

Chromosomes, Human, 1-3
Salmonella enterica
Escherichia coli
5' Flanking Region
Glucose
phosphoenolpyruvate phosphatase
Genes

Keywords

  • Acid phosphatase
  • Enterobacterial chromosome
  • Genetic rearrangement
  • Regulation
  • Salmonella enterica

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Genetic rearrangements in the tyrB-uvrA region of the enterobacterial chromosome : A potential cause for different class B acid phosphatase regulation in Salmonella enterica and Escherichia coli. / Thaller, Maria Cristina; Schippa, Serena; Bonci, Alessandra; Berlutti, Francesca; Selan, Laura; Rossolini, Gian Maria.

In: FEMS Microbiology Letters, Vol. 181, No. 1, 01.12.1999, p. 17-23.

Research output: Contribution to journalArticle

Thaller, Maria Cristina ; Schippa, Serena ; Bonci, Alessandra ; Berlutti, Francesca ; Selan, Laura ; Rossolini, Gian Maria. / Genetic rearrangements in the tyrB-uvrA region of the enterobacterial chromosome : A potential cause for different class B acid phosphatase regulation in Salmonella enterica and Escherichia coli. In: FEMS Microbiology Letters. 1999 ; Vol. 181, No. 1. pp. 17-23.
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