Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

Matteo Cereda; Thanos P. Mourikis; Francesca D. Ciccarelli

doi:10.1016/j.trecan.2016.03.003

Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

Matteo Cereda, Thanos P. Mourikis, Francesca D. Ciccarelli

Istituto Europeo di Oncologia

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

Original language	English
Pages (from-to)	160-162
Number of pages	3
Journal	Trends in Cancer
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.trecan.2016.03.003
Publication status	Published - Apr 1 2016

Keywords

cancer genomics
functional redundancy
paralog dependency
personalized medicine
synthetic lethality

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2016.03.003

Cite this

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title = "Genetic Redundancy, Functional Compensation, and Cancer Vulnerability",

abstract = "Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.",

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author = "Matteo Cereda and Mourikis, {Thanos P.} and Ciccarelli, {Francesca D.}",

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AU - Mourikis, Thanos P.

AU - Ciccarelli, Francesca D.

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Y1 - 2016/4/1

N2 - Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

AB - Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

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KW - functional redundancy

KW - paralog dependency

KW - personalized medicine

KW - synthetic lethality

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Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

Abstract

Keywords

ASJC Scopus subject areas

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