Abstract
Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.
Original language | English |
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Pages (from-to) | 160-162 |
Number of pages | 3 |
Journal | Trends in Cancer |
Volume | 2 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 1 2016 |
Keywords
- cancer genomics
- functional redundancy
- paralog dependency
- personalized medicine
- synthetic lethality
ASJC Scopus subject areas
- Oncology
- Cancer Research