Genetic Redundancy, Functional Compensation, and Cancer Vulnerability

Matteo Cereda, Thanos P. Mourikis, Francesca D. Ciccarelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer genomes acquire somatic alterations that largely differ between and within cancer types. Several of these alterations inactivate genes that are normally functional with no deleterious consequences on cancer cells due to genetic redundancy. Here we discuss how this leads to cancer synthetic dependencies that can be exploited in therapy.

Original languageEnglish
Pages (from-to)160-162
Number of pages3
JournalTrends in Cancer
Volume2
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • cancer genomics
  • functional redundancy
  • paralog dependency
  • personalized medicine
  • synthetic lethality

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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