Genetic regressive trajectories in colorectal cancer: A new hallmark of oligo-metastatic disease?

Alessandro Ottaiano, Mariachiara Santorsola, Michele Caraglia, Luisa Circelli, Valerio Gigantino, Gerardo Botti, Guglielmo Nasti

Research output: Contribution to journalReview articlepeer-review

Abstract

Colorectal cancer (CRC) originates as consequence of multiple genetic alterations. Some of the involved genes have been extensively studied (APC, TP53, KRAS, SMAD4, PIK3CA, MMR genes) in highly heterogeneous and poly-metastatic cohorts. However, about 10% of metastatic CRC patients presents with an indolent oligo-metastatic disease differently from other patients with poly-metastatic and aggressive clinical course. Which are the genetic dynamics underlying the differences between oligo- and poly-metastatic CRC? The understanding of the genetic trajectories (primary→metastatic) of CRC, in patients selected to represent homogenous clinical models, is crucial to make genotype/phenotype correlations and to identify the molecular events pushing the disease towards an increasing malignant phenotype. This information is crucial to plan innovative therapeutic strategies aimed to reverse or inhibit these phenomena. In the present study, we review the genetic evolution of CRC with the intent to give a developmental perspective on the border line between oligo- and poly-metastatic diseases.

Original languageEnglish
Article number101131
JournalTranslational Oncology
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Colorectal cancer
  • Genetics
  • Mutations
  • NGS
  • Oligo-metastases

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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