Genetic signature of adult gliomas and correlation with MRI features

Maria Grazia Bruzzone, Marica Eoli, Valeria Cuccarini, Marina Grisoli, Lorella Valletta, Gaetano Finocchiaro

Research output: Contribution to journalArticlepeer-review


In recent years the amount of information concerning the genetics and the biology of gliomas, and particularly of glioblastoma multiforme, increased steadily. Such an increase has been paralleled by the technological progress of MRI. The merging of these scientific areas, as summarized in this review, is helping the stratification of glioma patients for clinical trials and their clinical follow-up. Although available therapeutic options appear limited in number, it is likely that in the next 5 years, both as a consequence of the increased knowledge due to genomic sequencing of hundreds of glioblastoma specimens and to continuous improvements of MRI, new perspectives will be available for these patients, with a sizable impact on their prognosis.

Original languageEnglish
Pages (from-to)709-720
Number of pages12
JournalExpert Review of Molecular Diagnostics
Issue number7
Publication statusPublished - Oct 2009


  • EGF receptor amplification
  • Genetic marker
  • Glioma
  • Loss of heterozygosity
  • Methylation
  • MRI
  • Mutation
  • Prognosis

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Pathology and Forensic Medicine


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