Genetic susceptibility in pituitary adenomas: From pathogenesis to clinical implications

Marie Lise Jaffrain-Rea, Adrian F. Daly, Mariolina Angelini, Patrick Petrossians, Vincent Bours, Albert Beckers

Research output: Contribution to journalArticlepeer-review


Pituitary adenomas usually present sporadically, with a multifactorial pathogenesis including somatic mutational events in cancer-related genes. Genetic predisposition implies the presence of germline DNA alterations with a range of impacts on pituitary cell biology, translating into a variable penetrance of the disease. Genetic causes must be considered in the presence of specific clinical settings, such as familial occurrence of pituitary adenoma, with or without extrapituitary diseases, and may also be suspected in young patients (

Original languageEnglish
Pages (from-to)195-214
Number of pages20
JournalExpert Review of Endocrinology and Metabolism
Issue number2
Publication statusPublished - Mar 2011


  • AIP
  • aryl hydrocarbon receptor-interacting protein
  • Carney complex
  • familial isolated pituitary adenomas
  • FIPA
  • genetic screening
  • hereditary neoplasia
  • McCune-Albright syndrome
  • MEN1
  • multiple endocrine neoplasia type 1
  • pituitary adenoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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