Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium

Daniele Campa, Cosmeri Rizzato, Gabriele Capurso, Nathalia Giese, Niccola Funel, William Greenhalf, Pavel Soucek, Maria Gazouli, Raffaele Pezzilli, Claudio Pasquali, Renata Talar-Wojnarowska, Maurizio Cantore, Angelo Andriulli, Aldo Scarpa, Krzysztof Jamroziak, Gianfranco Delle Fave, Eithne Costello, Kay Tee Khaw, Anette Heller, Tim J. KeyGeorge Theodoropoulos, Ewa Malecka-Panas, Andrea Mambrini, Franco Bambi, Stefano Landi, Sergio Pedrazzoli, Claudio Bassi, Paola Pacetti, Ada Piepoli, Francesca Tavano, Pierluigi di Sebastiano, Ludmila Vodickova, Daniela Basso, Mario Plebani, Paola Fogar, Markus W. Büchler, Peter Bugert, Pavel Vodicka, Ugo Boggi, John P. Neoptolemos, Jens Werner, Federico Canzian, Gianfranco Delle Faveb, Nathalia Giese, Anette Heller, Markus W. Büchler, J. Jens Werner, Niccola Funel, Ugo Boggi, William Greenhalf, Eithne Costello, John P. Neoptolemos, Pavel Soucek, Maria Gazouli, George Theodoropoulos, Raffaele Pezzilli, Claudio Pasquali, Sergio Pedrazzoli, Renata Talar-Wojnarowska, Ewa Malecka-Panas, Maurizio Cantore, Andrea Mambrini, Paola Pacetti, Angelo Andriulli, Ada Piepolil, Francesca Tavano, Pierluigi di Sebastiano, Aldo Scarpa, Krzysztof Jamroziak, Kay Tee Khaw, Tim J. Key, Franco Bambi, Stefano Landi, Claudio Bassi, Pavel Vodicka, Ludmila Vodickova, Daniela Basso, Mario Plebani, Paola Fogar, Peter Bugert

Research output: Contribution to journalArticle

Abstract

Pancreatic cancer is the fourth leading cause of cancer deaths in the European Union and in the USA, but little is known about its genetic susceptibility. The PANcreatic Disease ReseArch (PANDoRA) consortium was established to unite the efforts of different research groups; its aim is to create a large bio-database to uncover new genetic factors for pancreatic cancer risk, response to treatment, and patient survival. So far 2220 cases of pancreatic adenocarcinoma, a smaller number of cases of endocrine pancreatic tumours (n= 86), chronic pancreatitis (n= 272) and 3847 healthy controls have been collected. As a collective effort of the consortium, SNPs associated with pancreatic adenocarcinoma risk from a genome-wide association study performed in Caucasians were replicated. The possibility that the same genetic polymorphisms may influence patient survival as well was also addressed. This collective effort is particularly important for pancreatic cancer because it is a relatively rare disease for which little is known about aetiopathogenesis and risk factors. The recruitment of additional collaborators and partner institutions is continuously on-going.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalDigestive and Liver Disease
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Cancer susceptibility
  • Genetic polymorphisms
  • Genetic susceptibility
  • Pancreatic cancer

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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  • Cite this

    Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., Soucek, P., Gazouli, M., Pezzilli, R., Pasquali, C., Talar-Wojnarowska, R., Cantore, M., Andriulli, A., Scarpa, A., Jamroziak, K., Fave, G. D., Costello, E., Khaw, K. T., Heller, A., ... Bugert, P. (2013). Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. Digestive and Liver Disease, 45(2), 95-99. https://doi.org/10.1016/j.dld.2012.09.014