TY - JOUR
T1 - Genetic trajectory and immune microenvironment of lung-specific oligometastatic colorectal cancer
AU - Ottaiano, Alessandro
AU - Circelli, Luisa
AU - Lombardi, Angela
AU - Scala, Stefania
AU - Martucci, Nicola
AU - Galon, Jerome
AU - Buonanno, Manuela
AU - Scognamiglio, Giosuè
AU - Botti, Gerardo
AU - Hermitte, Fabienne
AU - Savarese, Giovanni
AU - D’Amore, Luigi
AU - Tatangelo, Fabiana
AU - Di Mauro, Annabella
AU - Liguori, Giuseppina
AU - Trotta, Anna Maria
AU - Napolitano, Maria
AU - Capozzi, Monica
AU - Tafuto, Salvatore
AU - Perri, Francesco
AU - La Rocca, Antonello
AU - Caraglia, Michele
AU - Nasti, Guglielmo
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as only illness during their life in order to find any relevant genotype–phenotype relationship. Analysis of 523 cancer-relevant genes and of immune cells infiltration in primary and metastatic tissues revealed atypical genomic trajectories (TMB decrease, KRAS and SMAD4 regressive mutations), specific genetic events (ERBB2 point mutations) and scarce T-cell infiltration. These insights provide novel information in oligometastatic CRC biology and new perspectives for cancer monitoring and anti-cancer therapeutic strategies.
AB - Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from the primary tumor to the metastases are largely unknown; cancer heterogeneity makes challenging both therapy and mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as only illness during their life in order to find any relevant genotype–phenotype relationship. Analysis of 523 cancer-relevant genes and of immune cells infiltration in primary and metastatic tissues revealed atypical genomic trajectories (TMB decrease, KRAS and SMAD4 regressive mutations), specific genetic events (ERBB2 point mutations) and scarce T-cell infiltration. These insights provide novel information in oligometastatic CRC biology and new perspectives for cancer monitoring and anti-cancer therapeutic strategies.
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U2 - 10.1038/s41419-020-2480-6
DO - 10.1038/s41419-020-2480-6
M3 - Article
C2 - 32332709
AN - SCOPUS:85083837073
VL - 11
JO - Cell Death and Disease
JF - Cell Death and Disease
SN - 2041-4889
IS - 4
M1 - 275
ER -