Genetic transmission of migraine without aura: A study of 68 families

D. D'Amico, M. Leone, F. Macciardi, S. Valentini, G. Bussone

Research output: Contribution to journalArticlepeer-review

Abstract

68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalItalian Journal of Neurological Sciences
Volume12
Issue number6
DOIs
Publication statusPublished - Dec 1991

Keywords

  • "sex-limited" transmission
  • family history
  • genetic hypothesis
  • Migraine without aura

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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