Abstract
68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 581-584 |
| Number of pages | 4 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1991 |
Keywords
- "sex-limited" transmission
- family history
- genetic hypothesis
- Migraine without aura
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology