Abstract
68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 581-584 |
| Number of pages | 4 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1991 |
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Keywords
- "sex-limited" transmission
- family history
- genetic hypothesis
- Migraine without aura
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Genetic transmission of migraine without aura : A study of 68 families. / D'Amico, D.; Leone, M.; Macciardi, F.; Valentini, S.; Bussone, G.
In: Italian Journal of Neurological Sciences, Vol. 12, No. 6, 12.1991, p. 581-584.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic transmission of migraine without aura
T2 - A study of 68 families
AU - D'Amico, D.
AU - Leone, M.
AU - Macciardi, F.
AU - Valentini, S.
AU - Bussone, G.
PY - 1991/12
Y1 - 1991/12
N2 - 68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
AB - 68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.
KW - "sex-limited" transmission
KW - family history
KW - genetic hypothesis
KW - Migraine without aura
UR - http://www.scopus.com/inward/record.url?scp=0026276310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026276310&partnerID=8YFLogxK
U2 - 10.1007/BF02336955
DO - 10.1007/BF02336955
M3 - Article
C2 - 1783537
AN - SCOPUS:0026276310
VL - 12
SP - 581
EP - 584
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 6
ER -