Genetic transmission of migraine without aura: A study of 68 families

D. D'Amico; M. Leone; F. Macciardi; S. Valentini; G. Bussone

doi:10.1007/BF02336955

Genetic transmission of migraine without aura: A study of 68 families

D. D'Amico, M. Leone, F. Macciardi, S. Valentini, G. Bussone

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

68 randomly selected patients with migraine without aura (M) and 4 generations of their relatives (N=394) were studied in order to probe the genetic hypothesis of migraine. Significantly more of the probands were women and M was significantly more frequent among female relatives. Earlier onset was commoner among male probands. A genetic component of M is indicated by the very high frequency of at least one affected relative (85.3%) and by a disease prevalence that is similar among both first and second degree relatives. A simple autosomal mode of transmission seems unlikely from analysis of the data on the affected relatives, while a "sex-limited" transmission mode is suggested.

Original language	English
Pages (from-to)	581-584
Number of pages	4
Journal	Italian Journal of Neurological Sciences
Volume	12
Issue number	6
DOIs	https://doi.org/10.1007/BF02336955
Publication status	Published - Dec 1991

Keywords

"sex-limited" transmission
family history
genetic hypothesis
Migraine without aura

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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AU - Macciardi, F.

AU - Valentini, S.

AU - Bussone, G.

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