Genetic unresponsiveness to a murine fibrosarcoma determined by the host genetic environment but not by lymphocyte precursor genotype

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Abstract

(BALB/c x C3Hf) (H-2(d) x H-2(k))F1 hybrid mice but not parental BALB/c or other BALB/c x H-2(k) F1 hybrids, were unresponsive in transplantation and in neutralization (Winn) assay against a 3-methylcholanthrene-induced BALB/c fibrosarcoma. In BALB/c mice the antitumor activity revealed by Winn assay with antitumor immune lymphoid cells was shown to be tumor specific and mediated by Thy 1+ cells. Mouse chimeras were constructed by injecting fetal liver cells into irradiated recipients. Balb/c → (Balb/c x C3Hf)F1 and control (BALB/c x C3Hf)F1 → (BALB/c x C3Hf)F1 chimeras were unable to develop a transplantation immunity against the immunizing tumor, whereas (BALB/c x C3Hf)F1 → BALB/c chimeras were able to respond to the immunizing tumor. Thus, unresponsiveness was shown to be due to a defect in the maturation of precursor stem cells both of parental and F1 hybrid origin in the body of the (BALB/c x C3Hf)F1 animals.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalTumori
Volume71
Issue number2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cancer Research

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