Abstract
(BALB/c x C3Hf) (H-2(d) x H-2(k))F1 hybrid mice but not parental BALB/c or other BALB/c x H-2(k) F1 hybrids, were unresponsive in transplantation and in neutralization (Winn) assay against a 3-methylcholanthrene-induced BALB/c fibrosarcoma. In BALB/c mice the antitumor activity revealed by Winn assay with antitumor immune lymphoid cells was shown to be tumor specific and mediated by Thy 1+ cells. Mouse chimeras were constructed by injecting fetal liver cells into irradiated recipients. Balb/c → (Balb/c x C3Hf)F1 and control (BALB/c x C3Hf)F1 → (BALB/c x C3Hf)F1 chimeras were unable to develop a transplantation immunity against the immunizing tumor, whereas (BALB/c x C3Hf)F1 → BALB/c chimeras were able to respond to the immunizing tumor. Thus, unresponsiveness was shown to be due to a defect in the maturation of precursor stem cells both of parental and F1 hybrid origin in the body of the (BALB/c x C3Hf)F1 animals.
| Original language | English |
|---|---|
| Pages (from-to) | 91-96 |
| Number of pages | 6 |
| Journal | Tumori |
| Volume | 71 |
| Issue number | 2 |
| Publication status | Published - 1985 |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
Cite this
Genetic unresponsiveness to a murine fibrosarcoma determined by the host genetic environment but not by lymphocyte precursor genotype. / Colombo, M. P.; Rodolfo, M.; Parmiani, G.
In: Tumori, Vol. 71, No. 2, 1985, p. 91-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic unresponsiveness to a murine fibrosarcoma determined by the host genetic environment but not by lymphocyte precursor genotype
AU - Colombo, M. P.
AU - Rodolfo, M.
AU - Parmiani, G.
PY - 1985
Y1 - 1985
N2 - (BALB/c x C3Hf) (H-2(d) x H-2(k))F1 hybrid mice but not parental BALB/c or other BALB/c x H-2(k) F1 hybrids, were unresponsive in transplantation and in neutralization (Winn) assay against a 3-methylcholanthrene-induced BALB/c fibrosarcoma. In BALB/c mice the antitumor activity revealed by Winn assay with antitumor immune lymphoid cells was shown to be tumor specific and mediated by Thy 1+ cells. Mouse chimeras were constructed by injecting fetal liver cells into irradiated recipients. Balb/c → (Balb/c x C3Hf)F1 and control (BALB/c x C3Hf)F1 → (BALB/c x C3Hf)F1 chimeras were unable to develop a transplantation immunity against the immunizing tumor, whereas (BALB/c x C3Hf)F1 → BALB/c chimeras were able to respond to the immunizing tumor. Thus, unresponsiveness was shown to be due to a defect in the maturation of precursor stem cells both of parental and F1 hybrid origin in the body of the (BALB/c x C3Hf)F1 animals.
AB - (BALB/c x C3Hf) (H-2(d) x H-2(k))F1 hybrid mice but not parental BALB/c or other BALB/c x H-2(k) F1 hybrids, were unresponsive in transplantation and in neutralization (Winn) assay against a 3-methylcholanthrene-induced BALB/c fibrosarcoma. In BALB/c mice the antitumor activity revealed by Winn assay with antitumor immune lymphoid cells was shown to be tumor specific and mediated by Thy 1+ cells. Mouse chimeras were constructed by injecting fetal liver cells into irradiated recipients. Balb/c → (Balb/c x C3Hf)F1 and control (BALB/c x C3Hf)F1 → (BALB/c x C3Hf)F1 chimeras were unable to develop a transplantation immunity against the immunizing tumor, whereas (BALB/c x C3Hf)F1 → BALB/c chimeras were able to respond to the immunizing tumor. Thus, unresponsiveness was shown to be due to a defect in the maturation of precursor stem cells both of parental and F1 hybrid origin in the body of the (BALB/c x C3Hf)F1 animals.
UR - http://www.scopus.com/inward/record.url?scp=0021881469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021881469&partnerID=8YFLogxK
M3 - Article
C2 - 4002352
AN - SCOPUS:0021881469
VL - 71
SP - 91
EP - 96
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 2
ER -