Genetic vaccination by gene electro-transfer in non-human primates

I. Zampaglione, A. J. Simon, S. Capone, A. C. Finnefrock, D. R. Casimiro, G. S. Kath, A. Tang, A. Folgori, N. La Monica, J. Shiver, A. Nicosia, G. Ciliberto, R. Cortese, E. Fattori

Research output: Contribution to journalArticlepeer-review

Abstract

Muscle gene electro-transfer (GET) of plasmid DNA is a promising approach for gene therapy and genetic vaccination. Several protocols have been described which give good levels of gene transduction in small animals. However, to progress towards human applications, efficacy must be demonstrated in non-human primates. Here, we extensively explore several electrical and injection parameters in Rhesus monkeys and define a series of conditions for efficient vaccination.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalJournal of Drug Delivery Science and Technology
Volume16
Issue number1
Publication statusPublished - Jan 2006

Keywords

  • DNA vaccines
  • Gene electro-transfer
  • Non-human primates

ASJC Scopus subject areas

  • Pharmaceutical Science

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