TY - JOUR
T1 - Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection
AU - Sironi, Manuela
AU - Biasin, Mara
AU - Forni, Diego
AU - Cagliani, Rachele
AU - De Luca, Mariacristina
AU - Saulle, Irma
AU - Caputo, Sergio Lo
AU - Mazzotta, Francesco
AU - MacIas, Juan
AU - Pineda, Juan A.
AU - Caruz, Antonio
AU - Clerici, Mario
PY - 2012/7/17
Y1 - 2012/7/17
N2 - Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1 infection process, genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
AB - Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1 infection process, genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
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U2 - 10.1097/QAD.0b013e328354b3c2
DO - 10.1097/QAD.0b013e328354b3c2
M3 - Article
C2 - 22526516
AN - SCOPUS:84863723886
VL - 26
SP - 1443
EP - 1445
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 11
ER -