Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection

Manuela Sironi, Mara Biasin, Diego Forni, Rachele Cagliani, Mariacristina De Luca, Irma Saulle, Sergio Lo Caputo, Francesco Mazzotta, Juan MacIas, Juan A. Pineda, Antonio Caruz, Mario Clerici

Research output: Contribution to journalArticle

Abstract

Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1 infection process, genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.

Original languageEnglish
Pages (from-to)1443-1445
Number of pages3
JournalAIDS (London, England)
Volume26
Issue number11
DOIs
Publication statusPublished - Jul 17 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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