Genetic variability in E6 and E7 genes of human papillomavirus -16, -18, -31 and -33 from HIV-1-positive women in Italy

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Abstract

Among 544 HIV-positive women screened for HPV-DNA between 2003 and 2005, 265 (48.7%) were HPV-positive: 24 (9.1%) harboured HPV-16, 21 (7.9%) HPV-31, 12 (4.5%) HPV-18, 7 (2.6%) HPV-33. E6 and E7 of these HPV types were sequenced to assess their diversity. Ranges of inter- and intra-variant diversity were 1.2-3-3%, and 0.8-1.8 for E6 and 0.6-2.7%, and 0.6-2.0% for E7, respectively. HPV-31, the second most common HPV type, showed the highest diversity for both regions. On the whole, 26 out of 59 mutations were non-synonymous. The variability of these proteins may have implications in HPV vaccine strategies.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalNew Microbiologica
Volume30
Issue number4
Publication statusPublished - Oct 2007

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Keywords

  • Genotypes
  • HIV-1
  • Human papillomavirus (HPV)
  • Variants
  • Women

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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