TY - JOUR
T1 - Genetic variability in E6 and E7 genes of human papillomavirus -16, -18, -31 and -33 from HIV-1-positive women in Italy
AU - Garbuglia, Anna Rosa
AU - Carletti, Fabrizio
AU - Minosse, Claudia
AU - Piselli, Pierluca
AU - Zaniratti, M. Stefania
AU - Serraino, Diego
AU - Capobianchi, M. Rosaria
PY - 2007/10
Y1 - 2007/10
N2 - Among 544 HIV-positive women screened for HPV-DNA between 2003 and 2005, 265 (48.7%) were HPV-positive: 24 (9.1%) harboured HPV-16, 21 (7.9%) HPV-31, 12 (4.5%) HPV-18, 7 (2.6%) HPV-33. E6 and E7 of these HPV types were sequenced to assess their diversity. Ranges of inter- and intra-variant diversity were 1.2-3-3%, and 0.8-1.8 for E6 and 0.6-2.7%, and 0.6-2.0% for E7, respectively. HPV-31, the second most common HPV type, showed the highest diversity for both regions. On the whole, 26 out of 59 mutations were non-synonymous. The variability of these proteins may have implications in HPV vaccine strategies.
AB - Among 544 HIV-positive women screened for HPV-DNA between 2003 and 2005, 265 (48.7%) were HPV-positive: 24 (9.1%) harboured HPV-16, 21 (7.9%) HPV-31, 12 (4.5%) HPV-18, 7 (2.6%) HPV-33. E6 and E7 of these HPV types were sequenced to assess their diversity. Ranges of inter- and intra-variant diversity were 1.2-3-3%, and 0.8-1.8 for E6 and 0.6-2.7%, and 0.6-2.0% for E7, respectively. HPV-31, the second most common HPV type, showed the highest diversity for both regions. On the whole, 26 out of 59 mutations were non-synonymous. The variability of these proteins may have implications in HPV vaccine strategies.
KW - Genotypes
KW - HIV-1
KW - Human papillomavirus (HPV)
KW - Variants
KW - Women
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M3 - Article
C2 - 18080672
AN - SCOPUS:36549066142
VL - 30
SP - 377
EP - 382
JO - New Microbiologica
JF - New Microbiologica
SN - 1121-7138
IS - 4
ER -