Genetic variants of dopamine receptor D4 and psychopathology

A. Serretti, F. Macciardi, M. Catalano, L. Bellodi, E. Smeraldi

Research output: Contribution to journalArticle

Abstract

There is much evidence to indicate that the dopamine receptor D4 (DRD4) gene is involved in psychiatric disorders. As genetic liability may be expressed as psychopathological traits shared by several psychiatric disorders, we have developed a phenotypic definition based on the observed symptomatology independently of the clinical diagnosis. We investigated 461 inpatients affected by Schizophrenia and Mood Disorders assessed by the OP-CRIT (Operational Criteria checklist for psychotic illness) checklist and typed for DRD4 variants. The four symptomatologic factors, "Mania," "Depression," "Delusion," and "Disorganization" extracted from the Operational Criteria checklist for psychotic illness were used as phenotype definitions. DRD4 Exon 3 long allele variants were associated with high delusional scores, with the most significant difference between alleles 2 and 7 (P = 0.004). Consideration of possible stratification effects such as sex and psychiatric diagnosis did not affect the observed association. DRD4 variants may, therefore, constitute a liability factor for development of delusional symptomatology in patients that are affected by major psychoses.

Original languageEnglish
Pages (from-to)468
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume81
Issue number6
Publication statusPublished - Nov 6 1998

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Dopamine D4 Receptors
Dopamine Receptors
Checklist
Psychopathology
Psychiatry
Alleles
Delusions
Mood Disorders
Bipolar Disorder
Mental Disorders
Psychotic Disorders
Inpatients
Exons
Schizophrenia
Depression
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Serretti, A., Macciardi, F., Catalano, M., Bellodi, L., & Smeraldi, E. (1998). Genetic variants of dopamine receptor D4 and psychopathology. American Journal of Medical Genetics - Neuropsychiatric Genetics, 81(6), 468.

Genetic variants of dopamine receptor D4 and psychopathology. / Serretti, A.; Macciardi, F.; Catalano, M.; Bellodi, L.; Smeraldi, E.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 81, No. 6, 06.11.1998, p. 468.

Research output: Contribution to journalArticle

Serretti, A, Macciardi, F, Catalano, M, Bellodi, L & Smeraldi, E 1998, 'Genetic variants of dopamine receptor D4 and psychopathology', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 81, no. 6, pp. 468.
Serretti A, Macciardi F, Catalano M, Bellodi L, Smeraldi E. Genetic variants of dopamine receptor D4 and psychopathology. American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 Nov 6;81(6):468.
Serretti, A. ; Macciardi, F. ; Catalano, M. ; Bellodi, L. ; Smeraldi, E. / Genetic variants of dopamine receptor D4 and psychopathology. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 1998 ; Vol. 81, No. 6. pp. 468.
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