Genetic variants of the renin-angiotensin-aldosterone system and reverse remodeling after cardiac resynchronization therapy

Renata De Maria, Maurizio Landolina, Maurizio Gasparini, Boris Schmitz, Jonica Campolo, Marina Parolini, Antonio Sanzo, Paola Galimberti, Michele Bianchi, Stefan Martin Brand, Oberdan Parodi, Maurizio Lunati

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. Methods and Results: We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was defined as a >15% decrease in left ventricular end systolic volume (LVESV) at 9 (interquartile range 7-12) months after CRT. We matched 76 patients who did not show RR (RR-) to 80 RR+ control subjects by age, sex, HF etiology, New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF). The frequency of the minor allele of the NR3C2 gene (rs5522 C/T), encoding the mineralocorticoid receptor, was higher in RR- than in RR (24/126 vs 10/150; P value after false discovery rate correction:

Original languageEnglish
Pages (from-to)762-768
Number of pages7
JournalJournal of Cardiac Failure
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 2012

Keywords

  • cardiac resynchronization therapy
  • Heart failure
  • mineralocorticoid receptor
  • NR3C2
  • reverse remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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