Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and nutrition (EPIC) Cohort

Eric J. Duell, Núria Sala, Noémie Travier, Xavier Muñoz, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Aurelio Barricarte, Larraitz Arriola, Carmen Navarro, Emilio Sánchez-cantalejo, J. Ramón Quirós, Vittorio Krogh, Paolo Vineis, Amalia Mattiello, Rosario Tumino, Kay Tee Khaw, Nicholas Wareham, Naomi E. Allen, Petra H. Peeters, Mattijs E. Numans & 23 others H. B. Bueno-de-mesquita, M. G H Van Oijen, Christina Bamia, Vassiliki Benetou, Dimitrios Trichopoulos, Federico Canzian, Rudolf Kaaks, Heiner Boeing, Manuela M. Bergmann, Eiliv Lund, Roy Ehrnström, Dorthe Johansen, Göran Hallmans, Roger Stenling, Anne Tjønneland, Kim Overvad, Jane Nautrup Ostergaard, Pietro Ferrari, Veronika Fedirko, Mazda Jenab, Gabriella Nesi, Elio Riboli, Carlos A. González

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Abstract

Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases and 1272 controls) within the European Prospective Investigation into Cancer and Nutrition cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. We observed a statistically significant association between a common 3'-flanking SNP near ADH1A (rs1230025) and GC risk [allelic odds ratio (OR) A v T = 1.30, 95% confidence interval (CI) = 1.07-1.59]. Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (OR T v C = 0.59; 95% CI = 0.38-0.91 and OR T v C = 1.34; 95% CI = 1.00-1.79, respectively). Individuals carrying variant alleles at both ADH1 (rs1230025) and ALDH2 (rs16941667) were twice as likely to develop GC (OR A+T = 2.0; 95% CI = 1.25-3.20) as those not carrying variant alleles. The association between rs1230025 and GC was modified by alcohol intake (A = 0.89, 95% CI = 0.57-1.39; ≥5 g/day: OR A = 1.45, 95% CI = 1.08-1.94, P-value = 0.05). The association was also modified by ethanol intake from beer. A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. Variants in ADH7 were not associated with alcohol intake or GC risk. In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. Additional population-based studies are needed to confirm our results.

Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalCarcinogenesis
Volume33
Issue number2
DOIs
Publication statusPublished - 2012

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Aldehyde Dehydrogenase
Alcohol Dehydrogenase
Alcohol Drinking
Stomach Neoplasms
Odds Ratio
Alcohols
Confidence Intervals
Neoplasms
Single Nucleotide Polymorphism
Alleles
Multigene Family
Case-Control Studies
Ethanol

ASJC Scopus subject areas

  • Cancer Research

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Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and nutrition (EPIC) Cohort. / Duell, Eric J.; Sala, Núria; Travier, Noémie; Muñoz, Xavier; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Françoise; Barricarte, Aurelio; Arriola, Larraitz; Navarro, Carmen; Sánchez-cantalejo, Emilio; Quirós, J. Ramón; Krogh, Vittorio; Vineis, Paolo; Mattiello, Amalia; Tumino, Rosario; Khaw, Kay Tee; Wareham, Nicholas; Allen, Naomi E.; Peeters, Petra H.; Numans, Mattijs E.; Bueno-de-mesquita, H. B.; Van Oijen, M. G H; Bamia, Christina; Benetou, Vassiliki; Trichopoulos, Dimitrios; Canzian, Federico; Kaaks, Rudolf; Boeing, Heiner; Bergmann, Manuela M.; Lund, Eiliv; Ehrnström, Roy; Johansen, Dorthe; Hallmans, Göran; Stenling, Roger; Tjønneland, Anne; Overvad, Kim; Ostergaard, Jane Nautrup; Ferrari, Pietro; Fedirko, Veronika; Jenab, Mazda; Nesi, Gabriella; Riboli, Elio; González, Carlos A.

In: Carcinogenesis, Vol. 33, No. 2, 2012, p. 361-367.

Research output: Contribution to journalArticle

Duell, EJ, Sala, N, Travier, N, Muñoz, X, Boutron-Ruault, MC, Clavel-Chapelon, F, Barricarte, A, Arriola, L, Navarro, C, Sánchez-cantalejo, E, Quirós, JR, Krogh, V, Vineis, P, Mattiello, A, Tumino, R, Khaw, KT, Wareham, N, Allen, NE, Peeters, PH, Numans, ME, Bueno-de-mesquita, HB, Van Oijen, MGH, Bamia, C, Benetou, V, Trichopoulos, D, Canzian, F, Kaaks, R, Boeing, H, Bergmann, MM, Lund, E, Ehrnström, R, Johansen, D, Hallmans, G, Stenling, R, Tjønneland, A, Overvad, K, Ostergaard, JN, Ferrari, P, Fedirko, V, Jenab, M, Nesi, G, Riboli, E & González, CA 2012, 'Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and nutrition (EPIC) Cohort', Carcinogenesis, vol. 33, no. 2, pp. 361-367. https://doi.org/10.1093/carcin/bgr285
Duell, Eric J. ; Sala, Núria ; Travier, Noémie ; Muñoz, Xavier ; Boutron-Ruault, Marie Christine ; Clavel-Chapelon, Françoise ; Barricarte, Aurelio ; Arriola, Larraitz ; Navarro, Carmen ; Sánchez-cantalejo, Emilio ; Quirós, J. Ramón ; Krogh, Vittorio ; Vineis, Paolo ; Mattiello, Amalia ; Tumino, Rosario ; Khaw, Kay Tee ; Wareham, Nicholas ; Allen, Naomi E. ; Peeters, Petra H. ; Numans, Mattijs E. ; Bueno-de-mesquita, H. B. ; Van Oijen, M. G H ; Bamia, Christina ; Benetou, Vassiliki ; Trichopoulos, Dimitrios ; Canzian, Federico ; Kaaks, Rudolf ; Boeing, Heiner ; Bergmann, Manuela M. ; Lund, Eiliv ; Ehrnström, Roy ; Johansen, Dorthe ; Hallmans, Göran ; Stenling, Roger ; Tjønneland, Anne ; Overvad, Kim ; Ostergaard, Jane Nautrup ; Ferrari, Pietro ; Fedirko, Veronika ; Jenab, Mazda ; Nesi, Gabriella ; Riboli, Elio ; González, Carlos A. / Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and nutrition (EPIC) Cohort. In: Carcinogenesis. 2012 ; Vol. 33, No. 2. pp. 361-367.
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abstract = "Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases and 1272 controls) within the European Prospective Investigation into Cancer and Nutrition cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. We observed a statistically significant association between a common 3'-flanking SNP near ADH1A (rs1230025) and GC risk [allelic odds ratio (OR) A v T = 1.30, 95{\%} confidence interval (CI) = 1.07-1.59]. Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (OR T v C = 0.59; 95{\%} CI = 0.38-0.91 and OR T v C = 1.34; 95{\%} CI = 1.00-1.79, respectively). Individuals carrying variant alleles at both ADH1 (rs1230025) and ALDH2 (rs16941667) were twice as likely to develop GC (OR A+T = 2.0; 95{\%} CI = 1.25-3.20) as those not carrying variant alleles. The association between rs1230025 and GC was modified by alcohol intake (A = 0.89, 95{\%} CI = 0.57-1.39; ≥5 g/day: OR A = 1.45, 95{\%} CI = 1.08-1.94, P-value = 0.05). The association was also modified by ethanol intake from beer. A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. Variants in ADH7 were not associated with alcohol intake or GC risk. In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. Additional population-based studies are needed to confirm our results.",
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T1 - Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and nutrition (EPIC) Cohort

AU - Duell, Eric J.

AU - Sala, Núria

AU - Travier, Noémie

AU - Muñoz, Xavier

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Barricarte, Aurelio

AU - Arriola, Larraitz

AU - Navarro, Carmen

AU - Sánchez-cantalejo, Emilio

AU - Quirós, J. Ramón

AU - Krogh, Vittorio

AU - Vineis, Paolo

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Allen, Naomi E.

AU - Peeters, Petra H.

AU - Numans, Mattijs E.

AU - Bueno-de-mesquita, H. B.

AU - Van Oijen, M. G H

AU - Bamia, Christina

AU - Benetou, Vassiliki

AU - Trichopoulos, Dimitrios

AU - Canzian, Federico

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Bergmann, Manuela M.

AU - Lund, Eiliv

AU - Ehrnström, Roy

AU - Johansen, Dorthe

AU - Hallmans, Göran

AU - Stenling, Roger

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Ostergaard, Jane Nautrup

AU - Ferrari, Pietro

AU - Fedirko, Veronika

AU - Jenab, Mazda

AU - Nesi, Gabriella

AU - Riboli, Elio

AU - González, Carlos A.

PY - 2012

Y1 - 2012

N2 - Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases and 1272 controls) within the European Prospective Investigation into Cancer and Nutrition cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. We observed a statistically significant association between a common 3'-flanking SNP near ADH1A (rs1230025) and GC risk [allelic odds ratio (OR) A v T = 1.30, 95% confidence interval (CI) = 1.07-1.59]. Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (OR T v C = 0.59; 95% CI = 0.38-0.91 and OR T v C = 1.34; 95% CI = 1.00-1.79, respectively). Individuals carrying variant alleles at both ADH1 (rs1230025) and ALDH2 (rs16941667) were twice as likely to develop GC (OR A+T = 2.0; 95% CI = 1.25-3.20) as those not carrying variant alleles. The association between rs1230025 and GC was modified by alcohol intake (A = 0.89, 95% CI = 0.57-1.39; ≥5 g/day: OR A = 1.45, 95% CI = 1.08-1.94, P-value = 0.05). The association was also modified by ethanol intake from beer. A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. Variants in ADH7 were not associated with alcohol intake or GC risk. In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. Additional population-based studies are needed to confirm our results.

AB - Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases and 1272 controls) within the European Prospective Investigation into Cancer and Nutrition cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. We observed a statistically significant association between a common 3'-flanking SNP near ADH1A (rs1230025) and GC risk [allelic odds ratio (OR) A v T = 1.30, 95% confidence interval (CI) = 1.07-1.59]. Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (OR T v C = 0.59; 95% CI = 0.38-0.91 and OR T v C = 1.34; 95% CI = 1.00-1.79, respectively). Individuals carrying variant alleles at both ADH1 (rs1230025) and ALDH2 (rs16941667) were twice as likely to develop GC (OR A+T = 2.0; 95% CI = 1.25-3.20) as those not carrying variant alleles. The association between rs1230025 and GC was modified by alcohol intake (A = 0.89, 95% CI = 0.57-1.39; ≥5 g/day: OR A = 1.45, 95% CI = 1.08-1.94, P-value = 0.05). The association was also modified by ethanol intake from beer. A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. Variants in ADH7 were not associated with alcohol intake or GC risk. In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. Additional population-based studies are needed to confirm our results.

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