Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

Daniele Campa, James McKay, Olga Sinilnikova, Anika Hüsing, Ulla Vogel, Rikke Dalgaard Hansen, Kim Overvad, Petra Mariann Witt, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Veronique Chajes, Sabine Rohrmann, Jenny Chang-Claude, Heiner Boeing, Eva Fisher, Antonia Trichopoulou, Dimitrios Trichopoulos, Domenico Palli, Anna Villarini, Carlotta SacerdoteAmalia Mattiello, Rosario Tumino, Petra H M Peeters, Carla H. Van Gils, H. Bas Bueno-De-Mesquita, Eiliv Lund, María Dolores Chirlaque, Núria Sala, Laudina Rodriguez Suarez, Aurelio Barricarte, Miren Dorronsoro, Maria José Sánchez, Per Lenner, Göran Hallmans, Kostas Tsilidis, Sheila Bingham, Kay Tee Khaw, Valentina Gallo, Teresa Norat, Elio Riboli, Sabina Rinaldi, Gilbert Lenoir, Sean V. Tavtigian, Federico Canzian, Rudolf Kaaks

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

Original languageEnglish
Pages (from-to)565-574
Number of pages10
JournalBreast Cancer Research and Treatment
Volume118
Issue number3
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Fatty Acid Synthases
Single Nucleotide Polymorphism
Response Elements
Fatty Acids
Breast Neoplasms
Carrier Proteins
Body Mass Index
Genes
Carbohydrates
Malonyl Coenzyme A
Lipogenesis
Acetyl Coenzyme A
Palmitic Acid
Hormone Replacement Therapy
Sterols
Phosphatidylinositol 3-Kinases
NADP
Signal Transduction
Transcription Factors
Databases

Keywords

  • Body-mass index
  • Breast cancer
  • Carbohydrate response element-binding protein
  • Fatty acid synthase
  • Sterol response element-binding protein-1
  • Susceptibility to cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Campa, D., McKay, J., Sinilnikova, O., Hüsing, A., Vogel, U., Hansen, R. D., ... Kaaks, R. (2009). Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. Breast Cancer Research and Treatment, 118(3), 565-574. https://doi.org/10.1007/s10549-009-0347-8

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. / Campa, Daniele; McKay, James; Sinilnikova, Olga; Hüsing, Anika; Vogel, Ulla; Hansen, Rikke Dalgaard; Overvad, Kim; Witt, Petra Mariann; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie Christine; Chajes, Veronique; Rohrmann, Sabine; Chang-Claude, Jenny; Boeing, Heiner; Fisher, Eva; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Palli, Domenico; Villarini, Anna; Sacerdote, Carlotta; Mattiello, Amalia; Tumino, Rosario; Peeters, Petra H M; Van Gils, Carla H.; Bas Bueno-De-Mesquita, H.; Lund, Eiliv; Chirlaque, María Dolores; Sala, Núria; Suarez, Laudina Rodriguez; Barricarte, Aurelio; Dorronsoro, Miren; Sánchez, Maria José; Lenner, Per; Hallmans, Göran; Tsilidis, Kostas; Bingham, Sheila; Khaw, Kay Tee; Gallo, Valentina; Norat, Teresa; Riboli, Elio; Rinaldi, Sabina; Lenoir, Gilbert; Tavtigian, Sean V.; Canzian, Federico; Kaaks, Rudolf.

In: Breast Cancer Research and Treatment, Vol. 118, No. 3, 12.2009, p. 565-574.

Research output: Contribution to journalArticle

Campa, D, McKay, J, Sinilnikova, O, Hüsing, A, Vogel, U, Hansen, RD, Overvad, K, Witt, PM, Clavel-Chapelon, F, Boutron-Ruault, MC, Chajes, V, Rohrmann, S, Chang-Claude, J, Boeing, H, Fisher, E, Trichopoulou, A, Trichopoulos, D, Palli, D, Villarini, A, Sacerdote, C, Mattiello, A, Tumino, R, Peeters, PHM, Van Gils, CH, Bas Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Suarez, LR, Barricarte, A, Dorronsoro, M, Sánchez, MJ, Lenner, P, Hallmans, G, Tsilidis, K, Bingham, S, Khaw, KT, Gallo, V, Norat, T, Riboli, E, Rinaldi, S, Lenoir, G, Tavtigian, SV, Canzian, F & Kaaks, R 2009, 'Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk', Breast Cancer Research and Treatment, vol. 118, no. 3, pp. 565-574. https://doi.org/10.1007/s10549-009-0347-8
Campa, Daniele ; McKay, James ; Sinilnikova, Olga ; Hüsing, Anika ; Vogel, Ulla ; Hansen, Rikke Dalgaard ; Overvad, Kim ; Witt, Petra Mariann ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie Christine ; Chajes, Veronique ; Rohrmann, Sabine ; Chang-Claude, Jenny ; Boeing, Heiner ; Fisher, Eva ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Palli, Domenico ; Villarini, Anna ; Sacerdote, Carlotta ; Mattiello, Amalia ; Tumino, Rosario ; Peeters, Petra H M ; Van Gils, Carla H. ; Bas Bueno-De-Mesquita, H. ; Lund, Eiliv ; Chirlaque, María Dolores ; Sala, Núria ; Suarez, Laudina Rodriguez ; Barricarte, Aurelio ; Dorronsoro, Miren ; Sánchez, Maria José ; Lenner, Per ; Hallmans, Göran ; Tsilidis, Kostas ; Bingham, Sheila ; Khaw, Kay Tee ; Gallo, Valentina ; Norat, Teresa ; Riboli, Elio ; Rinaldi, Sabina ; Lenoir, Gilbert ; Tavtigian, Sean V. ; Canzian, Federico ; Kaaks, Rudolf. / Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. In: Breast Cancer Research and Treatment. 2009 ; Vol. 118, No. 3. pp. 565-574.
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AU - Hansen, Rikke Dalgaard

AU - Overvad, Kim

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AU - Clavel-Chapelon, Françoise

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AU - Chang-Claude, Jenny

AU - Boeing, Heiner

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AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Villarini, Anna

AU - Sacerdote, Carlotta

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Peeters, Petra H M

AU - Van Gils, Carla H.

AU - Bas Bueno-De-Mesquita, H.

AU - Lund, Eiliv

AU - Chirlaque, María Dolores

AU - Sala, Núria

AU - Suarez, Laudina Rodriguez

AU - Barricarte, Aurelio

AU - Dorronsoro, Miren

AU - Sánchez, Maria José

AU - Lenner, Per

AU - Hallmans, Göran

AU - Tsilidis, Kostas

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Gallo, Valentina

AU - Norat, Teresa

AU - Riboli, Elio

AU - Rinaldi, Sabina

AU - Lenoir, Gilbert

AU - Tavtigian, Sean V.

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KW - Sterol response element-binding protein-1

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