Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder

Riccardo Zuliani, T. William J Moorhead, Dominic Job, James McKirdy, Jessika E D Sussmann, Eve C. Johnstone, Stephen M. Lawrie, Paolo Brambilla, Jeremy Hall, Andrew M. McIntosh

Research output: Contribution to journalArticle

Abstract

Background: Variation in the G72 (DAOA) gene is understood to convey susceptibility for bipolar disorder through an uncertain mechanism. Little is known about the structural brain phenotypes associated with this gene. We hypothesised that reductions in temporal lobe and amygdala gray matter would be associated with variation at two loci in the gene for which evidence of genetic linkage has been repeatedly demonstrated. Methods: We examined the temporal lobe and amygdala gray matter associations of the risk variants M23 and M24 at the 5′ end of the gene encoding G72 in 81 controls and 38 people with bipolar disorder. Results: Genetic variation at both the M23 and M24 loci in G72 were associated with decreased gray matter density within the left temporal pole in people with bipolar disorder. M23 was also associated with reductions in right amygdala gray matter density. The genetic imaging associations were found only in patients with bipolar disorder. Conclusions: Genetic variation at single nucleotide polymorphisms in the G72 gene previously associated with bipolar disorder is related to reductions in temporal pole and amygdala gray matter structure in people with bipolar disorder.

Original languageEnglish
Pages (from-to)621-627
Number of pages7
JournalBipolar Disorders
Volume11
Issue number6
DOIs
Publication statusPublished - 2009

Keywords

  • Bipolar disorder
  • DAOA
  • G72
  • MRI
  • Voxel based morphometry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder'. Together they form a unique fingerprint.

  • Cite this

    Zuliani, R., Moorhead, T. W. J., Job, D., McKirdy, J., Sussmann, J. E. D., Johnstone, E. C., Lawrie, S. M., Brambilla, P., Hall, J., & McIntosh, A. M. (2009). Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder. Bipolar Disorders, 11(6), 621-627. https://doi.org/10.1111/j.1399-5618.2009.00731.x