Genetically modified immunocompetent cells in HIV infection

G. Palù, G. Li Pira, F. Gennari, D. Fenoglio, C. Parolin, F. Manca

Research output: Contribution to journalArticle

Abstract

Even in the era of highly active antiretroviral therapy (HAART), gene therapy (GT) can remain a promising approach for suppressing HIV infection, especially if complemented with other forms of pharmacological and immunological intervention. A large number of vectors and targets have been studied. Here we discuss the potential of genetically treated, antigen-specific immunocompetent cells for adoptive autologous immunotherapy of HIV infection. Cellular therapies with gene-modified CD8 and CD4 lymphocytes are aimed at reconstituting the antigen-specific repertoires that may be deranged as a consequence of HIV infection. Even if complete eradication of HIV from the reservoirs cannot be achieved, reconstitution of cellular immunity specific for opportunistic pathogens and for HIV itself is a desirable option to control progression of HIV infection and AIDS pathogenesis better.

Original languageEnglish
Pages (from-to)1593-1600
Number of pages8
JournalGene Therapy
Volume8
Issue number21
DOIs
Publication statusPublished - 2001

Keywords

  • Cell therapy
  • Gene therapy
  • HIV
  • Immunoreconstitution
  • Opportunistic pathogens
  • T cell repertoire

ASJC Scopus subject areas

  • Genetics

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