Genetics of adrenal tumors

G. Opocher, F. Schiavi, M. V. Cicala, A. Patalano, B. Mariniello, F. Boaretto, S. Zovato, V. Pignataro, B. Macino, I. Negro, F. Mantero

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The impact of genetics and genomics on clinical medicine is becoming more and more important Endocrinology pioneered the development of molecular medicine, but also the study of adrenal tumors had a great impact in this field. Particularly important was the detection of genetics of tumors derived from the adrenal medulla, as well as that of those derived from the sympathetic and parasympathetic paraganglia. The identification of mutations in one of the several pheochromocytoma/paraganglioma susceptibility genes may indicate a specific clinical management drive. Less well understood is the genetics of adrenal cortex tumors, in particular adrenocortical carcinoma, a rare and particularly aggressive disease. There are only a few examples of hereditary transmission of adrenocortical carcinoma, but the analysis of low penetrance genes by genome wide association study may enable us to discover new genetic mechanisms responsible for adrenocortical-derived tumors.

Original languageEnglish
Pages (from-to)107-121
Number of pages15
JournalMinerva Endocrinologica
Volume34
Issue number2
Publication statusPublished - Jun 2009

Fingerprint

Glandular and Epithelial Neoplasms
Molecular Medicine
Adrenocortical Carcinoma
Paraganglioma
Neoplasms
Adrenal Medulla
Penetrance
Endocrinology
Genome-Wide Association Study
Adrenal Cortex
Clinical Medicine
Pheochromocytoma
Genomics
Genes
Mutation

Keywords

  • Adrenal gland
  • Genetics
  • Genomics
  • Neoplasms

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology
  • Medicine(all)

Cite this

Opocher, G., Schiavi, F., Cicala, M. V., Patalano, A., Mariniello, B., Boaretto, F., ... Mantero, F. (2009). Genetics of adrenal tumors. Minerva Endocrinologica, 34(2), 107-121.

Genetics of adrenal tumors. / Opocher, G.; Schiavi, F.; Cicala, M. V.; Patalano, A.; Mariniello, B.; Boaretto, F.; Zovato, S.; Pignataro, V.; Macino, B.; Negro, I.; Mantero, F.

In: Minerva Endocrinologica, Vol. 34, No. 2, 06.2009, p. 107-121.

Research output: Contribution to journalArticle

Opocher, G, Schiavi, F, Cicala, MV, Patalano, A, Mariniello, B, Boaretto, F, Zovato, S, Pignataro, V, Macino, B, Negro, I & Mantero, F 2009, 'Genetics of adrenal tumors', Minerva Endocrinologica, vol. 34, no. 2, pp. 107-121.
Opocher G, Schiavi F, Cicala MV, Patalano A, Mariniello B, Boaretto F et al. Genetics of adrenal tumors. Minerva Endocrinologica. 2009 Jun;34(2):107-121.
Opocher, G. ; Schiavi, F. ; Cicala, M. V. ; Patalano, A. ; Mariniello, B. ; Boaretto, F. ; Zovato, S. ; Pignataro, V. ; Macino, B. ; Negro, I. ; Mantero, F. / Genetics of adrenal tumors. In: Minerva Endocrinologica. 2009 ; Vol. 34, No. 2. pp. 107-121.
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