Genetics of Amyotrophic Lateral Sclerosis

K. P. Kenna, J. E. Landers, N. Ticozzi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The identification of disease-causing mutations has proven to be essential for our understanding of the pathogenesis and progression of human disorders. The identification of such genes can lead to new avenues of research and may be even used for diagnostic testing purposes. Novel disease-gene identification leads to the development of cellular and animal models that are invaluable in the characterization of disease-related biological pathways and allow investigation into the potential efficacy of therapeutic strategies. Here, we examine how genes associated with amyotrophic lateral sclerosis have allowed us to identify several pathways affected by mutations which may ultimately lead to therapeutic strategies.

Original languageEnglish
Title of host publicationMolecular and Cellular Therapies for Motor Neuron Diseases
PublisherElsevier Inc.
Pages43-59
Number of pages17
ISBN (Print)9780128022573
DOIs
Publication statusPublished - Jan 19 2017

Keywords

  • Aggregation disease mechanisms
  • ALS
  • Genetics
  • Heritability
  • Pathology

ASJC Scopus subject areas

  • Neuroscience(all)

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    Kenna, K. P., Landers, J. E., & Ticozzi, N. (2017). Genetics of Amyotrophic Lateral Sclerosis. In Molecular and Cellular Therapies for Motor Neuron Diseases (pp. 43-59). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802257-3.00003-1