Genetics of epilepsy: Epilepsy Research Foundation workshop report

Sanjay Sisodiya, J. Helen Cross, Ingmar Blümcke, David Chadwick, John Craig, Peter B. Crino, Paul Debenham, Norman Delanty, Frances Elmslie, Mark Gardiner, Jeffrey Golden, David Goldstein, David A. Greenberg, Renzo Guerrini, Michael Hanna, John Harris, Paul Harrison, Michael R. Johnson, George Kirov, Dimitri M. KullmanAndrew Makoff, Carla Marini, Rima Nabbout, Lina Nashef, Jeffrey L. Noebels, Ruth Ottman, Munir Pirmohamed, Asla Pitkänen, Ingrid Scheffer, Simon Shorvon, Graeme Sills, Nicholas Wood, Sameer Zuberi

Research output: Contribution to journalArticlepeer-review

Abstract

The Sixth Epilepsy Research Foundation workshop, held in Oxford in March 2006, brought together basic scientists, geneticists, epidemiologists, statisticians, pharmacologists and clinicians to consider progress, issues and strategies for harnessing genetics to improve the understanding and treatment of the epilepsies. General principles were considered, including the fundamental importance of clear study design, adequate patient numbers, defined phenotypes, robust statistical data handling, and follow-up of genetic discoveries. Topics where some progress had been made were considered including chromosomal abnormalities, neurodevelopment, hippocampal sclerosis, juvenile myoclonic epilepsy, focal cortical dysplasia and pharmacogenetics. The ethical aspects of epilepsy genetics were reviewed. Principles and limitations of collaboration were discussed. Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy.

Original languageEnglish
Pages (from-to)194
Number of pages1
JournalEpileptic Disorders
Volume9
Issue number2
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Anti-epileptic drug
  • Chromosome
  • Epilepsy
  • Genetics
  • Pharmacogenetics

ASJC Scopus subject areas

  • Clinical Neurology

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