Genetica dell'emicrania emiplegica familiare: Stato dell'arte

Translated title of the contribution: Genetics of familial hemiplegic Migraine: State of the art

S. Battistini, P. Carrera

Research output: Contribution to journalArticlepeer-review

Abstract

At present, very few is known on the genetics of common Migraines, most likely to be considered a multifactorial disease. Recently, the CACNA1A gene encoding the brain-specific P/Q type calcium channel alpha 1 subunit, has been cloned and mutations in this gene, located on chromosome 19p13, have been shown to be involved in familial hemiplegic migraine (FHM), a rare autosomal dominantly inherited subtype of migraine with aura. Being part of the migraine spectrum, FHM represents a good model to study the genetics of more common forms of migraine. Different classes of mutations within the CACNA1A gene have been associated with different diseases, thus identifying a new member among 'channelopathies'. Variable clinical expression and genetic heterogeneity of FHM will be discussed.

Translated title of the contributionGenetics of familial hemiplegic Migraine: State of the art
Original languageItalian
Pages (from-to)109-115
Number of pages7
JournalConfinia Cephalalgica
Volume9
Issue number3
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Genetics of familial hemiplegic Migraine: State of the art'. Together they form a unique fingerprint.

Cite this