Genetics of ischemic stroke, stroke-related risk factors, stroke precursors and treatments

David Della-Morte, Fiorella Guadagni, Raffaele Palmirotta, Gianluca Testa, Valeria Caso, Maurizio Paciaroni, Pasquale Abete, Franco Rengo, Patrizia Ferroni, Ralph L. Sacco, Tatjana Rundek

Research output: Contribution to journalArticle

Abstract

Stroke remains a leading cause of death worldwide and the first cause of disability in the western world. Ischemic stroke (IS) accounts for almost 80% of the total cases of strokes and is a complex and multifactorial disease caused by the combination of vascular risk factors, environment and genetic factors. Investigations of the genetics of atherosclerosis and IS has greatly enhanced our knowledge of this complex multifactorial disease. In this article we sought to review common single-gene disorders relevant to IS, summarize candidate gene and genome-wide studies aimed at discovering genetic stroke risk factors and subclinical phenotypes, and to briefly discuss pharmacogenetics related to stroke treatments. Genetics of IS is, in fact, one of the most promising research frontiers and genetic testing may be helpful for novel drug discoveries as well as for appropriate drug and dose selection for treatment of patients with cerebrovascular disease.

Original languageEnglish
Pages (from-to)595-613
Number of pages19
JournalPharmacogenomics
Volume13
Issue number5
DOIs
Publication statusPublished - Apr 2012

Keywords

  • atherosclerosis
  • carotid intima-media thickness
  • carotid plaque
  • genes
  • genome-wide association study
  • ischemic stroke
  • monogenic stroke
  • pharmacogenetics
  • SNPs
  • vascular risk factors

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine

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  • Cite this

    Della-Morte, D., Guadagni, F., Palmirotta, R., Testa, G., Caso, V., Paciaroni, M., Abete, P., Rengo, F., Ferroni, P., Sacco, R. L., & Rundek, T. (2012). Genetics of ischemic stroke, stroke-related risk factors, stroke precursors and treatments. Pharmacogenomics, 13(5), 595-613. https://doi.org/10.2217/pgs.12.14