Genetics of murine sarcoma virus (MSV) induced tumors in AKR mice: Evidence that late progressing and early regressing tumors are controlled by different genes

A. Colombatti, L. Chieco-Bianchi, A. de Rossi, E. D'Andrea, D. Collavo

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Abstract

The genetics of late appearing MSV tumors showing a progressive growth pattern in AKR mice was investigated. The late MSV tumor response in F 1 hybrids depended on the genetic background of the non-AKR parent. Within the 4-month observation period following virus injection, (CBAxAKR)F 1, (DBA/2xAKR)F 1, and (NIHxAKR)F 1 developed progressing MSV tumors, which exhibited latency and growth behavior comparable to that seen in AKR mice. (BALBxAKR)F 1, (B6xAKR)F 1, and (B10BRxAKR)F 1 mice did not show any late MSV tumors. In contrast to early regressing M-MSV tumors, whose development is independent of Fv-1 genotype, late MSV tumor progression is largely a function of this gene, since all late tumors which appeared in (B10BRxAKR)xAKR were observed in Fv-1(n) homozygous mice. H-2(k) haplotype is a further factor in the occurrence of late MSV tumors, at least in (B6xAKR)xAKR mice. In crosses of AKR with Fv-1 compatible mice, tumor appearance was strongly associated with inheritance of AKR-MuLV, and MSV recovered from late tumors of first back-cross animals appeared to be a new pseudotype with the endogenous AKR-MuLV. It is suggested that the host genetic control in both early and late MSV tumors is exerted mainly on the helper component of the leukemia-sarcoma complex.

Original languageEnglish
Pages (from-to)565-575
Number of pages11
JournalInternational Journal of Cancer
Volume19
Issue number4
Publication statusPublished - 1977

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Murine Sarcoma Viruses
Inbred AKR Mouse
Genes
Neoplasms
Growth
Sarcoma
Haplotypes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Genetics of murine sarcoma virus (MSV) induced tumors in AKR mice : Evidence that late progressing and early regressing tumors are controlled by different genes. / Colombatti, A.; Chieco-Bianchi, L.; de Rossi, A.; D'Andrea, E.; Collavo, D.

In: International Journal of Cancer, Vol. 19, No. 4, 1977, p. 565-575.

Research output: Contribution to journalArticle

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AU - Collavo, D.

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