Genetics of renal damage in primary hypertension

D. Cusi, G. Tripodi, G. Casari, C. Robba, P. Bollini, G. Merati, G. Bianchi

Research output: Contribution to journalArticle

Abstract

Little is known of the genetics of glomerular damage in essential hypertension in humans. The prevalence of end-stage renal disease due to primary hypertension varies from 20% to 30% of all cases of renal failure to as low as 0.002%. This depends not only on differences in diagnostic criteria but also on different racial susceptibility to the disease as well as on different genetic backgrounds in different subsets of individuals of the same race. A review of the literature is provided, together with an example of how a point mutation that causes hypertension in Milan hypertensive rats can provide a model to analyze this issue correctly.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume21
Issue number5 SUPPL. 2
Publication statusPublished - 1993

Fingerprint

Hypertension
Kidney
Disease Susceptibility
Point Mutation
Chronic Kidney Failure
Renal Insufficiency
Genetic Background
Essential Hypertension

Keywords

  • Genetics
  • Hypertension
  • Kidney
  • Pathophysiology

ASJC Scopus subject areas

  • Nephrology

Cite this

Cusi, D., Tripodi, G., Casari, G., Robba, C., Bollini, P., Merati, G., & Bianchi, G. (1993). Genetics of renal damage in primary hypertension. American Journal of Kidney Diseases, 21(5 SUPPL. 2), 2-9.

Genetics of renal damage in primary hypertension. / Cusi, D.; Tripodi, G.; Casari, G.; Robba, C.; Bollini, P.; Merati, G.; Bianchi, G.

In: American Journal of Kidney Diseases, Vol. 21, No. 5 SUPPL. 2, 1993, p. 2-9.

Research output: Contribution to journalArticle

Cusi, D, Tripodi, G, Casari, G, Robba, C, Bollini, P, Merati, G & Bianchi, G 1993, 'Genetics of renal damage in primary hypertension', American Journal of Kidney Diseases, vol. 21, no. 5 SUPPL. 2, pp. 2-9.
Cusi D, Tripodi G, Casari G, Robba C, Bollini P, Merati G et al. Genetics of renal damage in primary hypertension. American Journal of Kidney Diseases. 1993;21(5 SUPPL. 2):2-9.
Cusi, D. ; Tripodi, G. ; Casari, G. ; Robba, C. ; Bollini, P. ; Merati, G. ; Bianchi, G. / Genetics of renal damage in primary hypertension. In: American Journal of Kidney Diseases. 1993 ; Vol. 21, No. 5 SUPPL. 2. pp. 2-9.
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