Genetics of renal damage in primary hypertension

D. Cusi, G. Tripodi, G. Casari, C. Robba, P. Bollini, G. Merati, G. Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

Little is known of the genetics of glomerular damage in essential hypertension in humans. The prevalence of end-stage renal disease due to primary hypertension varies from 20% to 30% of all cases of renal failure to as low as 0.002%. This depends not only on differences in diagnostic criteria but also on different racial susceptibility to the disease as well as on different genetic backgrounds in different subsets of individuals of the same race. A review of the literature is provided, together with an example of how a point mutation that causes hypertension in Milan hypertensive rats can provide a model to analyze this issue correctly.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume21
Issue number5 SUPPL. 2
Publication statusPublished - 1993

Keywords

  • Genetics
  • Hypertension
  • Kidney
  • Pathophysiology

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Genetics of renal damage in primary hypertension'. Together they form a unique fingerprint.

Cite this