Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

Juliane Winkelmann, Oli Polo, Federica Provini, Sonja Nevsimalova, David Kemlink, Karel Sonka, Birgit Högl, Werner Poewe, Karin Stiasny-Kolster, Wolfgang Oertel, Al De Weerd, Luigi Ferini Strambi, Marco Zucconi, Peter P. Pramstaller, Isabelle Arnulf, Claudia Trenkwalder, Christine Klein, Georgios M. Hadjigeorgiou, Svenja Happe, David RyePasquale Montagna

Research output: Contribution to journalArticle

Abstract

Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.

Original languageEnglish
JournalMovement Disorders
Volume22
Issue numberSUPPL. 18
DOIs
Publication statusPublished - 2007

Keywords

  • Genetics
  • Restless legs syndrome
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Winkelmann, J., Polo, O., Provini, F., Nevsimalova, S., Kemlink, D., Sonka, K., Högl, B., Poewe, W., Stiasny-Kolster, K., Oertel, W., De Weerd, A., Strambi, L. F., Zucconi, M., Pramstaller, P. P., Arnulf, I., Trenkwalder, C., Klein, C., Hadjigeorgiou, G. M., Happe, S., ... Montagna, P. (2007). Genetics of restless legs syndrome (RLS): State-of-the-art and future directions. Movement Disorders, 22(SUPPL. 18). https://doi.org/10.1002/mds.21587