TY - JOUR
T1 - Genetics of vascular dementia - review from the ICVD working group
AU - Ikram, M. Arfan
AU - Ikram, M. Arfan
AU - Ikram, M. Arfan
AU - Ikram, M. Arfan
AU - Bersano, Anna
AU - Manso-Calderón, Raquel
AU - Manso-Calderón, Raquel
AU - Jia, Jian Ping
AU - Schmidt, Helena
AU - Middleton, Lefkos
AU - Nacmias, Benedetta
AU - Siddiqi, Saima
AU - Adams, Hieab H.H.
AU - Adams, Hieab H.H.
PY - 2017/3/6
Y1 - 2017/3/6
N2 - © 2017 The Author(s). Background: Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms could improve our understanding of vascular dementia, leading to a potential translation of this knowledge to clinical practice. Discussion: In this review, we discuss what is currently known about the genetics of vascular dementia. The identification of causal genes remains limited to monogenic forms of the disease, with findings for sporadic vascular dementia being less robust. However, progress in genetic research on associated phenotypes, such as cerebral small vessel disease, Alzheimer's disease, and stroke, have the potential to inform on the genetics of vascular dementia. We conclude by providing an overview of future developments in the field and how such work could impact patients and clinicians. Conclusion: The genetic background of vascular dementia is well established for monogenic disorders, but remains relatively obscure for the sporadic form. More work is needed for providing robust findings that might eventually lead to clinical translation.
AB - © 2017 The Author(s). Background: Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms could improve our understanding of vascular dementia, leading to a potential translation of this knowledge to clinical practice. Discussion: In this review, we discuss what is currently known about the genetics of vascular dementia. The identification of causal genes remains limited to monogenic forms of the disease, with findings for sporadic vascular dementia being less robust. However, progress in genetic research on associated phenotypes, such as cerebral small vessel disease, Alzheimer's disease, and stroke, have the potential to inform on the genetics of vascular dementia. We conclude by providing an overview of future developments in the field and how such work could impact patients and clinicians. Conclusion: The genetic background of vascular dementia is well established for monogenic disorders, but remains relatively obscure for the sporadic form. More work is needed for providing robust findings that might eventually lead to clinical translation.
KW - Cerebral small vessel disease
KW - Genetics
KW - Magnetic resonance imaging
KW - Vascular dementia
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U2 - 10.1186/s12916-017-0813-9
DO - 10.1186/s12916-017-0813-9
M3 - Review article
C2 - 28260527
AN - SCOPUS:85014471229
VL - 15
JO - BMC Medicine
JF - BMC Medicine
SN - 1741-7015
IS - 1
ER -