Genistein trjggers apoftosis of chronic myelogenous leukemia cells and selects bcr/abl negative progenitors

V. Rizzoli, E. Regazzi, G. Dotti, L. Mangoni, D. Garau, M. T. Rizzo, B. Savoldo, A. Bonari, C. Carlo-Stella

Research output: Contribution to journalArticle

Abstract

Chronic myelogenous leukemia (CML) is characterized by a chimeric BCR/ABL gene giving rise to fusion protein with increased tyrosine kinase activity. Genistein is a protein tyrosine kinase inhibitor. The aims of the present study were: (1) to evaluate the effects of genistein on the growth of primitive (long-term culture-initiating cells, LTC-IC) and committed

Original languageEnglish
Pages (from-to)1142
Number of pages1
JournalExperimental Hematology
Volume24
Issue number9
Publication statusPublished - 1996

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Genistein
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Protein Kinase Inhibitors
Cell Culture Techniques
Growth
Genes
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Genistein trjggers apoftosis of chronic myelogenous leukemia cells and selects bcr/abl negative progenitors. / Rizzoli, V.; Regazzi, E.; Dotti, G.; Mangoni, L.; Garau, D.; Rizzo, M. T.; Savoldo, B.; Bonari, A.; Carlo-Stella, C.

In: Experimental Hematology, Vol. 24, No. 9, 1996, p. 1142.

Research output: Contribution to journalArticle

Rizzoli, V, Regazzi, E, Dotti, G, Mangoni, L, Garau, D, Rizzo, MT, Savoldo, B, Bonari, A & Carlo-Stella, C 1996, 'Genistein trjggers apoftosis of chronic myelogenous leukemia cells and selects bcr/abl negative progenitors', Experimental Hematology, vol. 24, no. 9, pp. 1142.
Rizzoli V, Regazzi E, Dotti G, Mangoni L, Garau D, Rizzo MT et al. Genistein trjggers apoftosis of chronic myelogenous leukemia cells and selects bcr/abl negative progenitors. Experimental Hematology. 1996;24(9):1142.
Rizzoli, V. ; Regazzi, E. ; Dotti, G. ; Mangoni, L. ; Garau, D. ; Rizzo, M. T. ; Savoldo, B. ; Bonari, A. ; Carlo-Stella, C. / Genistein trjggers apoftosis of chronic myelogenous leukemia cells and selects bcr/abl negative progenitors. In: Experimental Hematology. 1996 ; Vol. 24, No. 9. pp. 1142.
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