Genital and inguinal cutaneous toxicity in male and female patients treated with sunitinib

Roberto Iacovelli, Maria Laura Mancini, Emanuela Risi, Antonella Palazzo, Enrico Cortesi

Research output: Contribution to journalArticle

Abstract

Background Sunitinib is an orally tyrosine kinase inhibitor currently approved by the Food and Drug Administration for the treatment of advanced renal cell carcinoma (RCC) and gastrointestinal stromal tumor. Several cutaneous toxicities have been observed with Sunitinib and among those scrotal cutaneous toxicity could affect 12.5% of patients after an average 66 days of exposure to treatment. Objective We report the first case of a female patient who develops vulvar toxicity during sunitinib treatment. Subjects and Methods A 68-year-old female patient was treated with sunitinib at standard dose of 50 mg/daily for four weeks on and two weeks off, for advanced clear cell RCC. During week 2 of the second cycle of sunitinib, the patient reported vulvar pain and itching. Results Local examination revealed erythema of the outer lips and two erythematosus areas localized on the upper medial area of the legs. The sunitinib was discontinued, and the signs and symptoms disappeared completely seven days after drug interruption without any specific treatment. Conclusion Female genital cutaneous toxicity with sunitinib shows a similar behavior as found in males, and both should be carefully evaluated even if the treatment discontinuation is generally not required.

Original languageEnglish
Pages (from-to)221-222
Number of pages2
JournalInternational Journal of Dermatology
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2012

ASJC Scopus subject areas

  • Dermatology

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