Genome search in celiac disease

Luigi Greco, Gino Corazza, Marie Claude Babron, Fabienne Clot, Marie Claude Fulchignoni-Lataud, Selvaggia Percopo, Patrizia Zavattari, Faouzi Bouguerra, Colette Dib, Roberto Tosi, Riccardo Troncone, Alessandro Ventura, Wilma Mantavoni, Giuseppe Magazzù, Rosanna Gatti, Rosanna Lazzari, Annamaria Giunta, Francesco Perri, Giuseppe Iacono, Ettore CardiStefano De Virgiliis, Francesco Cataldo, Gianluigi De Angelis, Salvatore Musumeci, Roberto Ferrari, Fiorella Balli, Maria Teresa Bardella, Umberto Volta, Carlo Catassi, Giuliano Torre, Jean François Eliaou, Jean Louis Serre, Françoise Clerget-Darpoux

Research output: Contribution to journalArticle

Abstract

Celiac disease (CD), a malabsorption disorder of the small intestine, results from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the entire genetic susceptibility. To determine the localization of other genetic risk factors, a systematic screening of the genome has been undertaken. The typing information of 281 markers on 110 affected sib pairs and their parents was used to test linkage. Systematic linkage analysis was first performed on 39 pairs in which both sibs had a symptomatic form of CD. Replication of the regions of interest was then carried out on 71 pairs in which one sib had a symptomatic form and the other a silent form of CD. In addition to the HLA loci, our study suggests that a risk factor in 5qter is involved in both forms of CD (symptomatic and silent). Furthermore, a factor on 11qter possibly differentiates the two forms. In contrast, none of the regions recently published was confirmed by the present screening.

Original languageEnglish
Pages (from-to)669-675
Number of pages7
JournalAmerican Journal of Human Genetics
Volume62
Issue number3
DOIs
Publication statusPublished - Mar 1998

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ASJC Scopus subject areas

  • Genetics

Cite this

Greco, L., Corazza, G., Babron, M. C., Clot, F., Fulchignoni-Lataud, M. C., Percopo, S., Zavattari, P., Bouguerra, F., Dib, C., Tosi, R., Troncone, R., Ventura, A., Mantavoni, W., Magazzù, G., Gatti, R., Lazzari, R., Giunta, A., Perri, F., Iacono, G., ... Clerget-Darpoux, F. (1998). Genome search in celiac disease. American Journal of Human Genetics, 62(3), 669-675. https://doi.org/10.1086/301754