Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset

Ying Jin, Stanca A. Birlea, Pamela R. Fain, Katherine Gowan, Sheri L. Riccardi, Paulene J. Holland, Dorothy C. Bennett, Deborah M. Herbstman, Margaret R. Wallace, Wayne T. McCormack, E. Helen Kemp, David J. Gawkrodger, Anthony P. Weetman, Mauro Picardo, Giovanni Leone, Alain Taïeb, Thomas Jouary, Khaled Ezzedine, Nanny Van Geel, Jo LambertAndreas Overbeck, Richard A. Spritz

Research output: Contribution to journalArticlepeer-review

Abstract

Generalized vitiligo is a common autoimmune disease in which acquired patchy depigmentation of skin, hair, and mucous membranes results from loss of melanocytes from involved areas. Previous genetic analyses have focused on vitiligo susceptibility, and have identified a number of genes involved in disease risk. Age of onset of generalized vitiligo also involves a substantial genetic component, but has not previously been studied systematically. In this study, we report a genome-wide association study of vitiligo age of onset in 1,339 generalized vitiligo patients, with replication in an independent cohort of 677 cases. We identified a quantitative trait locus for vitiligo age of onset in the major histocompatibility complex (MHC) class II region, located near c6orf10-BTNL2 (rs7758128; P8.14 × 10 11), a region that is also associated with generalized vitiligo susceptibility. In contrast, there was no association of vitiligo age of onset with any other MHC or non-MHC loci that are associated with vitiligo susceptibility. These findings highlight the differing roles played by genes involved in vitiligo susceptibility versus vitiligo age of onset, and illustrate that genome-wide analyses can be used to identify genes involved in quantitative aspects of disease natural history, as well as disease susceptibility per se.

Original languageEnglish
Pages (from-to)1308-1312
Number of pages5
JournalJournal of Investigative Dermatology
Volume131
Issue number6
DOIs
Publication statusPublished - Jun 2011

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset'. Together they form a unique fingerprint.

Cite this