Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster

Jan Rehwinkel, Andrea Herold, Kerstin Gari, Thomas Köcher, Michaela Rode, Francesca L. Ciccarelli, Matthias Wilm, Elisa Izaurralde

Research output: Contribution to journalArticlepeer-review

Abstract

In yeast cells, the THO complex has been implicated in mitotic recombination, transcription elongation and mRNA nuclear export. The stable core of THO consists of Tho2p, Hpr1p, Mft1p and Thp2p. Whether a complex with similar functions assembles in metazoa has not yet been established. Here we report that Drosophila melanogaster THO consists of THO2, HPR1 and three proteins, THOC5-THOC7, which have no orthologs in budding yeast. Gene expression profiling in cells depleted of THO components revealed that

Original languageEnglish
Pages (from-to)558-566
Number of pages9
JournalNature Structural and Molecular Biology
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 2004

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster'. Together they form a unique fingerprint.

Cite this