Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide

E Salvi, Z Wang, F Rizzi, Y Gong, CW McDonough, S Padmanabhan, TP Hiltunen, C Lanzani, R Zaninello, M Chittani, KR Bailey, AP Sarin, M Barcella, O Melander, AB Chapman, P Manunta, KK Kontula, N Glorioso, D Cusi, AF DominiczakJA Johnson, C Barlassina, E Boerwinkle, RM Cooper-DeHoff, ST Turner

Research output: Contribution to journalArticle

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Abstract

This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothiazide monotherapy. A genome-wide meta-analysis of blood pressure (BP) response to hydrochlorothiazide was performed in 1739 white hypertensives from 6 clinical trials within the International Consortium for Antihypertensive Pharmacogenomics Studies, making it the largest study to date of its kind. No signals reached genome-wide significance (P
Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalHypertension
Volume69
Issue number1
DOIs
Publication statusPublished - 2017

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Hydrochlorothiazide
Antihypertensive Agents
Meta-Analysis
Genome
Blood Pressure
Genes
Clinical Trials
Pharmacogenomic Testing

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Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide. / Salvi, E; Wang, Z; Rizzi, F; Gong, Y; McDonough, CW; Padmanabhan, S; Hiltunen, TP; Lanzani, C; Zaninello, R; Chittani, M; Bailey, KR; Sarin, AP; Barcella, M; Melander, O; Chapman, AB; Manunta, P; Kontula, KK; Glorioso, N; Cusi, D; Dominiczak, AF; Johnson, JA; Barlassina, C; Boerwinkle, E; Cooper-DeHoff, RM; Turner, ST.

In: Hypertension, Vol. 69, No. 1, 2017, p. 51-59.

Research output: Contribution to journalArticle

Salvi, E, Wang, Z, Rizzi, F, Gong, Y, McDonough, CW, Padmanabhan, S, Hiltunen, TP, Lanzani, C, Zaninello, R, Chittani, M, Bailey, KR, Sarin, AP, Barcella, M, Melander, O, Chapman, AB, Manunta, P, Kontula, KK, Glorioso, N, Cusi, D, Dominiczak, AF, Johnson, JA, Barlassina, C, Boerwinkle, E, Cooper-DeHoff, RM & Turner, ST 2017, 'Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide', Hypertension, vol. 69, no. 1, pp. 51-59. https://doi.org/10.1161/HYPERTENSIONAHA.116.08267
Salvi, E ; Wang, Z ; Rizzi, F ; Gong, Y ; McDonough, CW ; Padmanabhan, S ; Hiltunen, TP ; Lanzani, C ; Zaninello, R ; Chittani, M ; Bailey, KR ; Sarin, AP ; Barcella, M ; Melander, O ; Chapman, AB ; Manunta, P ; Kontula, KK ; Glorioso, N ; Cusi, D ; Dominiczak, AF ; Johnson, JA ; Barlassina, C ; Boerwinkle, E ; Cooper-DeHoff, RM ; Turner, ST. / Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide. In: Hypertension. 2017 ; Vol. 69, No. 1. pp. 51-59.
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