Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide

E Salvi, Z Wang, F Rizzi, Y Gong, CW McDonough, S Padmanabhan, TP Hiltunen, C Lanzani, R Zaninello, M Chittani, KR Bailey, AP Sarin, M Barcella, O Melander, AB Chapman, P Manunta, KK Kontula, N Glorioso, D Cusi, AF DominiczakJA Johnson, C Barlassina, E Boerwinkle, RM Cooper-DeHoff, ST Turner

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothiazide monotherapy. A genome-wide meta-analysis of blood pressure (BP) response to hydrochlorothiazide was performed in 1739 white hypertensives from 6 clinical trials within the International Consortium for Antihypertensive Pharmacogenomics Studies, making it the largest study to date of its kind. No signals reached genome-wide significance (P
Original languageEnglish
Pages (from-to)51-59
Number of pages9
JournalHypertension
Volume69
Issue number1
DOIs
Publication statusPublished - 2017

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