Genome-wide association studies in myocardial infarction and coronary artery disease

Pier Mannuccio Mannucci, Luca A. Lotta, Flora Peyvandi

Research output: Contribution to journalArticlepeer-review

Abstract

Myocardial infarction (MI) and its major determinant, coronary artery disease (CAD), are complex diseases arising from the interaction between several genetic and environmental factors. Until recently, the genetic basis of these diseases was poorly understood. Genome-wide genetic association studies have afforded a comprehensive insight into the association between genetic variants and diseases. To date, seven genome-wide association studies have been conducted in CAD/MI, identifying thirteen genomic regions at which common genetic variants influence the predisposition to these diseases. This review article summarizes the progress achieved in the genetic basis of MI and CAD by means of genome-wide association studies and the potential clinical applications of these findings.

Original languageEnglish
Pages (from-to)116-121
Number of pages6
JournalJournal of Tehran University Heart Center
Volume5
Issue number3
Publication statusPublished - 2010

Keywords

  • Coronary artery disease
  • Genome-wide association study
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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